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6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-二氧杂螺[2.13]十六烷-10,16-二酮

6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-二氧杂螺[2.13]十六烷-10,16-二酮

CAS号：4166-78-3

英文名：6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-8,14-dihydroxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione

分子式

C28H49NO9

熔点

密度

1.19g/cm3

分子量

543.69

沸点

707ºC at 760 mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-二氧杂螺[2.13]十六烷-10,16-二酮

英文名称

6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-8,14-dihydroxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione

中文别名

英文别名

6-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-8,14-dihydroxy-5,7,9,12,13,15-hexamethyl-2,11-dioxaspiro[2.13]hexadecane-10,16-dione、doleandomycin、Xylopyranoside,6R,12S-dihydroxy-5S,7S,8R,11R,13R,15R-hexamethyl-4,10-dioxo-1,9-dioxaspiro(2,13)hexadec-14R-yl 3,4,6-trideoxy-3-(dimethylamino)-,betaD、Desoleandomycin、Deoleandrosyl-oleandomycin

CAS号

4166-78-3

分子式

C28H49NO9

分子量

543.69

精确质量

543.341

PSA

138.29

LOGP

1.3734

物化性质

密度

1.19g/cm3

沸点

707ºC at 760 mmHg

闪点

381.4ºC

折射率

1.532

合成路线

竹桃霉素

6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-二氧杂螺[2.13]十六烷-10,16-二酮

6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-6-(4-二甲基氨基-3-羟基-6-甲基-四氢吡喃-2-基)氧基-8,14-二羟基-5,7,9,12,13,15-六甲基-1,11-二氧杂螺[2.13]十六烷-10,16-二酮

上游原料

共找到8个上游原料 >

(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-2-(pyrimidin-2-ylthio)tetrahydro-2H-pyran-3-yl acetate

(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-2-(pyrimidin-2-ylthio)tetrahydro-2H-pyran-3-yl acetate

(1S,2R,2'R,5R,6R,7S,8R,12S,13S,17R)-15-(4-bromophenyl)-7-hydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxirane]-3,9-dione

(1S,2R,2'R,5R,6R,7S,8R,12S,13S,17R)-15-(4-bromophenyl)-7-hydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxirane]-3,9-dione

竹桃霉素

(1S,2R,2'R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxiran]-3-one

(1S,2R,2'R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxiran]-3-one

(1S,2R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-10-methylene-4,14,16-trioxabicyclo[11.3.1]heptadecan-3-one

(1S,2R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-10-methylene-4,14,16-trioxabicyclo[11.3.1]heptadecan-3-one

上游原料

(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-2-(pyrimidin-2-ylthio)tetrahydro-2H-pyran-3-yl acetate 硫酸 (1S,2R,2'R,5R,6R,7S,8R,12S,13S,17R)-15-(4-bromophenyl)-7-hydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxirane]-3,9-dione 竹桃霉素 (1S,2R,2'R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-4,14,16-trioxaspiro[bicyclo[11.3.1]heptadecane-10,2'-oxiran]-3-one (1S,2R,5R,6R,7R,8R,9R,12S,13S,17R)-15-(4-bromophenyl)-7,9-dihydroxy-2,5,6,8,12,17-hexamethyl-10-methylene-4,14,16-trioxabicyclo[11.3.1]heptadecan-3-one Oleandolide (2S,3R,4S,6R)-2-(((3R,5R,6S,7R,8R,11R,12S,13S,14S,15S)-6,12-dihydroxy-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadecan-14-yl)oxy)-4-(dimethylamino)-6-methyltetrahydro-2H-pyran-3-yl acetate