化合物简介
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
基本信息
中文名称
5-(1H-吲哚-3-基甲基)-3-甲基-2-硫酮-4-咪唑烷酮
英文名称
5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
中文别名
Mth-DL-色氨酸
英文别名
MTH-DL-Tryptophan、Necrostatin 1、Necrostatin-1、methyl-thiohydantoin-tryptophan、Nec-1、MTH-trp、5-indol-3-ylmethyl-3-methyl-2-thioxo-imidazolidin-4-one、Necroptotic Inhibitor,Nec-1
CAS号
4311-88-0
分子式
C13H13N3OS
分子量
259.327
精确质量
259.078
PSA
80.22
LOGP
1.6922
编号系统
MDL号
MFCD00056916
物化性质
密度
1.4g/cm3
沸点
441.9ºC at 760mmHg
熔点
151ºC
闪点
221.1ºC
折射率
1.737
储存条件
-20ºC
安全信息
WGK Germany
3
海关编码
2933990090
