商品
首页 百科
NPI 0052

NPI 0052

CAS号：437742-34-2
英文名：salinosporamide A
分子式
C15H20ClNO4
熔点
密度
分子量
313.777
沸点
溶解度
信号词
危险品标志
若想填写更详细的询价信息，请点击进入询价页面
点我
化合物简介
Salinosporamide A is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marine natural product is produced by the obligate marine bacteria Salinispora tropica and Salinispora arenicola, which are found in ocean sediment. Salinosporamide A belongs to a family of compounds, known collectively as salinosporamides, which possess a densely functionalized γ-lactam-β-lactone bicyclic core.
基本信息
中文名称
NPI 0052
英文名称
salinosporamide A
中文别名
英文别名
MARIZOMIB、(1S,2R,5R)-2-(2-chloroethyl)-5-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-1-methyl-7-oxa-4-azabicyclo[3.2.0]heptane-3,6-dione、NPI-0052、UNII-703P9YDP7F
CAS号
437742-34-2
分子式
C15H20ClNO4
分子量
313.777
精确质量
313.108
PSA
79.12
LOGP
1.4087
编号系统
UNII
703P9YDP7F
物化性质
储存条件
4ºC
合成路线
(1R,4R,5S)-1-((S)-((S)-cyclohex-2-enyl)hydroxymethyl)-4-(2-hydroxyethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
823229-54-5
(1R,4R,5S)-1-((S)-((S)-cyclohex-2-enyl)hydroxymethyl)-4-(2-hydroxyethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
NPI 0052
437742-34-2
NPI 0052
上游原料
共找到72个上游原料 >
(2R,3aR,6S,8aS,8bS)-2-(benzyloxy)-6-(tert-butyl)-8b-methyl-4-oxotetrahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazole-8a(8H)-carbaldehyde
943542-46-9
(2R,3aR,6S,8aS,8bS)-2-(benzyloxy)-6-(tert-butyl)-8b-methyl-4-oxotetrahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazole-8a(8H)-carbaldehyde
(3aR,6R,6aS)-6-((S)-(S)-Cyclohex-2-enyl-hydroxy-methyl)-2-hydroxy-6a-methyl-4-oxo-hexahydro-furo[2,3-c]pyrrole-6-carboxylic acid tert-butyl ester
915315-31-0
(3aR,6R,6aS)-6-((S)-(S)-Cyclohex-2-enyl-hydroxy-methyl)-2-hydroxy-6a-methyl-4-oxo-hexahydro-furo[2,3-c]pyrrole-6-carboxylic acid tert-butyl ester
(2R,3S,4R)-2-[(S)-{(S)-cyclohex-2-enyl}hydroxymethyl]-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester
704910-41-8
(2R,3S,4R)-2-[(S)-{(S)-cyclohex-2-enyl}hydroxymethyl]-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester
tert-butyl (2R,3aR,6S,6aS)-2-(benzyloxy)-6-formyl-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate
856681-98-6
tert-butyl (2R,3aR,6S,6aS)-2-(benzyloxy)-6-formyl-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate
9-cyclohex-2-enyl-9-borabicyclo[3.3.1]nonane
61967-15-5
9-cyclohex-2-enyl-9-borabicyclo[3.3.1]nonane
6-benzyl 6-(tert-butyl) (2R,3aR,6S,6aS)-2-(benzyloxy)-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-6H-furo[2,3-c]pyrrole-6,6-dicarboxylate
856682-14-9
6-benzyl 6-(tert-butyl) (2R,3aR,6S,6aS)-2-(benzyloxy)-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-6H-furo[2,3-c]pyrrole-6,6-dicarboxylate
上游原料
(2R,3aR,6S,8aS,8bS)-2-(benzyloxy)-6-(tert-butyl)-8b-methyl-4-oxotetrahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazole-8a(8H)-carbaldehyde (3aR,6R,6aS)-6-((S)-(S)-Cyclohex-2-enyl-hydroxy-methyl)-2-hydroxy-6a-methyl-4-oxo-hexahydro-furo[2,3-c]pyrrole-6-carboxylic acid tert-butyl ester (2R,3S,4R)-2-[(S)-{(S)-cyclohex-2-enyl}hydroxymethyl]-3-hydroxy-4-(2-hydroxyethyl)-1-(4-methoxybenzyl)-3-methyl-5-oxopyrrolidine-2-carboxylic acid methyl ester tert-butyl (2R,3aR,6S,6aS)-2-(benzyloxy)-6-formyl-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate 9-cyclohex-2-enyl-9-borabicyclo[3.3.1]nonane 6-benzyl 6-(tert-butyl) (2R,3aR,6S,6aS)-2-(benzyloxy)-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-6H-furo[2,3-c]pyrrole-6,6-dicarboxylate (1R,4R,5S)-4-(2-chloroethyl)-1-((1S)-cyclohex-2-en-1-yl(hydroxy)methyl)-2-(4-methoxybenzyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (2R,3S,4R)-4-(2-(benzoyloxy)ethyl)-2-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carboxylic acid methyl (2R,3aR,6S,8aS,8bS)-2-(benzyloxy)-6-(tert-butyl)-8b-methyl-4-oxotetrahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazole-8a(8H)-carboxylate 2-((3R,4S,5R)-5-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-hydroxy-5-(hydroxymethyl)-4-methyl-2-oxopyrrolidin-3-yl)ethyl benzoate (1S,3R,5R,8R)-8-benzyloxycarbonyl-7-tert-butoxycarbonyl-8-((S)-((S)-cyclohex-2-enyl)(hydroxy)methyl)-3-methoxy-1-methyl-2-oxa-7-azabicyclo[3.3.0]octane-6-one (1R,4R,5S)-1-((S)-((S)-cyclohex-2-enyl)hydroxymethyl)-4-(2-hydroxyethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (1S,3S,5R)-8,8-dibenzyloxycarbonyl-3-methoxy-1-methyl-2-oxa-7-azabicyclo[3.3.0]octane-6-one (3S,3aS,7aR)-3-Formyl-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester (1S,3S,5R,8R)-8-benzyloxycarbonyl-7-tert-butoxycarbonyl-8-hydroxymethyl-3-methoxy-1-methyl-2-oxa-7-azabicyclo[3.3.0]octane-6-one methyl (2R,3S)-2-((benzyloxy)methyl)-3-(((bromomethyl)dimethylsilyl)oxy)-1-(4-methoxybenzyl)-3-methyl-4-methylene-5-oxopyrrolidine-2-carboxylate tert-butyl (2R,3S,4R)-2-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carboxylate (3S,6R,7S,7aR)-3-(tert-butyl)-7a-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-7-hydroxy-6-(2-hydroxyethyl)-7-methyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one tert-butyl (2R,3aR,6R,6aS)-2-(benzyloxy)-6-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate (3R,4S,5R,6R)-5-(2-(benzyloxy)ethyl)-4-hydroxy-6-methoxy-4-methyltetrahydro-2H-pyran-3-yl 4-methylbenzenesulfonate methyl (3S,6R,7S,7aS)-6-allyl-3-(tert-butyl)-7-hydroxy-7-methyl-5-oxodihydro-1H,3H-pyrrolo[1,2-c]oxazole-7a(5H)-carboxylate (2R,3aR,6S,8aS,8bS)-2-(benzyloxy)-6-(tert-butyl)-8a-(hydroxymethyl)-8b-methylhexahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazol-4-one (3R,4S,5R,6R)-5-(2-(benzyloxy)ethyl)-6-methoxy-4-methyltetrahydro-2H-pyran-3,4-diol (2R,3aR,6S,8aR,8bS)-2-(benzyloxy)-6-(tert-butyl)-8a-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-8b-methylhexahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazol-4-one (2R,3S,4R)-4-(2-chloroethyl)-2-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carboxylic acid methyl (2R,3S,4R)-2-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carboxylate methyl (4aR,7R,7aS)-7-(hydroxymethyl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate N-((3S,4S,5R,6R)-5-(2-(benzyloxy)ethyl)-6-methoxy-4-methyl-4-((trimethylsilyl)oxy)-3-vinyltetrahydro-2H-pyran-3-yl)-2,2,2-trichloroacetamide NPI-2076 methyl (3aR,6S,8aS,8bS)-6-(tert-butyl)-2-hydroxy-8b-methyl-4-oxotetrahydro-4H,6H-furo[2',3':3,4]pyrrolo[1,2-c]oxazole-8a(8H)-carboxylate (1R,4R,5S)-1-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-4-(2-hydroxyethyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione 2-((3S,6R,7S,7aR)-3-(tert-butyl)-7a-((R)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-7-hydroxy-7-methyl-5-oxotetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-6-yl)ethyl benzoate 2-((3R,4S,5R)-5-((R)-((S)-cyclohex-2-en-1-yl)((trimethylsilyl)oxy)methyl)-4-hydroxy-5-(hydroxymethyl)-4-methyl-2-oxopyrrolidin-3-yl)ethyl benzoate cyclohexa-1,3-diene methyl (4aR,7R,7aS)-7-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-6-(4-methoxybenzyl)-2,2,7a-trimethyl-5-oxooctahydro-[1,2]oxasilino[5,6-c]pyrrole-7-carboxylate (1S,3S,5R,8R)-8-benzyloxycarbonyl-8-(hydroxymethyl)-3-methoxy-1-methyl-2-oxa-7-azabicyclo[3.3.0]octane-6-one tert-butyl (2R,3aR,6R,6aS)-2-(benzyloxy)-6-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl)-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate benzyl ((3S,4S,5R,6R)-5-(2-(benzyloxy)ethyl)-6-methoxy-4-methyl-4-((trimethylsilyl)oxy)-3-vinyltetrahydro-2H-pyran-3-yl)carbamate (1S,3S,5R)-3-methoxy-8,8-di(methoxycarbonyl)-1-methyl-2-oxa-7-azabicyclo[3.3.0]octane-6-one NPI-2062 (4S,5R,6R)-5-(2-(benzyloxy)ethyl)-4-hydroxy-6-methoxy-4-methyldihydro-2H-pyran-3(4H)-one (3R,5S,6R)-5-(2-(benzyloxy)ethyl)-6-methoxy-4-oxotetrahydro-2H-pyran-3-yl 4-methylbenzenesulfonate tert-butyl (2R,3aR,6R,6aS)-2-(benzyloxy)-6-(hydroxymethyl)-5-(4-methoxybenzyl)-6a-methyl-4-oxohexahydro-2H-furo[2,3-c]pyrrole-6-carboxylate 2-((3aR,6R,7R,7aS)-6-methoxy-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-7-yl)ethanol
按化学品名称查询∶
ABCDEFGHIJKLMNOPQRSTUVWXYZ0123456789
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床判断或治疗，非药用，非食用。

增值电信业务许可证 举报电话: 400-612-5272

Copyright © Shanghai Milkyway Supply Chain Management Co., Ltd. 上海密尔克卫供应链管理有限公司 | 工商 经营证照 沪ICP备2024054240号-1