化合物简介
WAY-200070 is a synthetic, non-steroidal, highly selective agonist of ERβ. It possesses 68-fold selectivity for ERβ over ERα (EC50 = 2 nM and 155 nM, respectively). WAY-200070 has been found to enhance serotonergic and dopaminergic neurotransmission in the central nervous system, and produces antidepressant- and anxiolytic-like effects in animals. It has been proposed as a potential novel antidepressant/anxiolytic agent. WAY-200070 has also been found to produce antidiabetic effects in animals, and may also be beneficial for the treatment of certain inflammatory conditions.
基本信息
中文名称
4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one
英文名称
4-(7-bromo-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)cyclohexa-2,5-dien-1-one
中文别名
英文别名
7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol、5-Benzoxazolol,7-bromo-2-(4-hydroxyphenyl)、7-BROMO-2-(4-HYDROXYPHENYL)-1,3-BENZOXAZOL-5-OL、7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol、7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
CAS号
440122-66-7
分子式
C13H8BrNO3
分子量
306.112
精确质量
304.969
PSA
66.49
LOGP
3.6685
合成路线
