化合物简介
Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor. This mixture of activities gives eseroline an unusual pharmacological profile, although its uses are limited by side effects such as respiratory depression and neurotoxicity.
基本信息
中文名称
氧化毒扁豆碱
英文名称
eseroline
中文别名
英文别名
Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS-cis)-、(S)-(-)-4\',7-Isoflavandiol、(+/-)-Equol、7-hydroxy-3-(4-hydroxyphenyl)-1-benzopyran、3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol、1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol、(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol、4\',7-DIHYDROXYISOFLAVAN、R,S-EQUOL、(3S)-Equol、7,4\'-ISOFLAVANDIOL、EQUOL/()-4\'\',7-ISOFLAVANDIOL、(S)-EQUOL、(3AS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]-indol-5-ol、(-)-Eseroline、1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indol-5-ol、4\',7-ISOFLAVANDIOL、EQUOL,(+/-)-(SH)
CAS号
469-22-7
分子式
C13H18N2O
分子量
218.295
精确质量
218.142
PSA
26.71
LOGP
1.7642
物化性质
密度
1.16g/cm3
沸点
366.3ºC at 760mmHg
闪点
189.6ºC
折射率
1.597
蒸汽压
6.99E-06mmHg at 25°C
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