百科

甘草次酸

甘草次酸

CAS号：471-53-4

英文名：Enoxolone

分子式

C30H46O4

熔点

292 - 295ºC

密度

1.14g/cm3

分子量

470.684

沸点

588.3ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Enoxolone (INN, BAN; also known as glycyrrhetinic acid or glycyrrhetic acid) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties. It has some additional pharmacological properties including antiviral, antifungal, antiprotozoal, and antibacterial activities.

基本信息

中文名称

甘草次酸

英文名称

Enoxolone

中文别名

甘草次酸(β型)、(3β,20β)-3-羟基-11-氧代-齐墩果-12-烯-29-酸

英文别名

ENOLOXONE、biosone、glycyrrhetin、Glycyrrhetic acid、STX 352、URALENIC ACID、Glycyrrhetic Acid、glycyrrhetinic acid、Arthrodont、GM 1658、PO 12、18β-Glycyrrhetinic acid、18-beta-Glycyrrhetinic acid、18b-Glycyrrhetic acid

CAS号

471-53-4

分子式

C30H46O4

分子量

470.684

精确质量

470.34

PSA

74.6

LOGP

6.4126

编号系统

MDL号

MFCD00003706

物化性质

外观与性状

白色结晶粉末

密度

1.14g/cm3

沸点

588.3ºC at 760mmHg

熔点

292 - 295ºC

闪点

323.7ºC

稳定性

Stable under normal temperatures and pressures.

储存条件

Store in a cool, dry place. Store in a tightly closed container. Refrigerator (approx 4ºC).

蒸汽压

2.71E-16mmHg at 25°C

安全信息

安全说明

S22; S24/25

危险类别码

R22; R36

海关编码

2938909030

危险品标志

Xn

合成路线

共找到6条合成路线 >

18a-甘草素

D-葡糖醛酸

甘草次酸

3-epikatonic acid

3-epikatonic acid

上游原料

共找到9个上游原料 >

甘草酸铵

3-O-(beta-D-呋喃芹糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸

3-O-(beta-D-呋喃芹糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸

3-O-(alpha-L-阿拉伯吡喃糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸

3-O-(alpha-L-阿拉伯吡喃糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸

3-O-Acetyl-liquiritinsaeure

3-O-Acetyl-liquiritinsaeure

18a-甘草素

(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸

(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸

下游产品

共找到6个下游商品 >

2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸

2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸

(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸

(2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸

2-[[(4aR,6aS,6bR,8aS,11S,12aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,12a-十二氢苉-3-基]氧羰基]苯甲酸

2-[[(4aR,6aS,6bR,8aS,11S,12aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,12a-十二氢苉-3-基]氧羰基]苯甲酸

硬脂醇甘草亭酸酯

硬脂醇甘草亭酸酯

18α-甘草次酸

18α-甘草次酸

1,2,7-Trimethylnaphthalene

1,2,7-Trimethylnaphthalene

上游原料

甘草酸铵 3-O-(beta-D-呋喃芹糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸 3-O-(alpha-L-阿拉伯吡喃糖基(1-2)-beta-D-吡喃葡糖醛酸基)甘草次酸 3-O-Acetyl-liquiritinsaeure 18a-甘草素 (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸 6',6''-dibenzyl-18β-glycyrrhizin 甘草酸甲醇

下游产品

2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸 (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-羧基-4,4,6a,6b,8a,11,14b-七甲基-14-氧代-2,3,4a,5,6,7,8,9,10,12,12a,14a-十二氢-1H-苉-3-基]氧基]-3,4,5-三羟基四氢吡喃-2-羧酸 2-[[(4aR,6aS,6bR,8aS,11S,12aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,12a-十二氢苉-3-基]氧羰基]苯甲酸硬脂醇甘草亭酸酯 18α-甘草次酸 1,2,7-Trimethylnaphthalene