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N-甲基-N-((3R,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-D]嘧啶-4-胺

CAS号：477600-74-1

英文名：N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

分子式

C13H19N5

熔点

密度

1.197g/cm3

分子量

245.323

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

N-甲基-N-((3R,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-D]嘧啶-4-胺

英文名称

N-methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

中文别名

N-甲基-N-((3R,4R)-4-甲基-3-哌啶基)-7H-吡咯并[2,3-D]嘧啶-4-胺、n-甲基-n-[(3r,4r)-4-甲基-3-哌啶基]-7H-吡咯并[2,3-d]嘧啶-4-胺、托法替尼中间体

英文别名

tofacitinib intermediate

CAS号

477600-74-1

分子式

C13H19N5

分子量

245.323

精确质量

245.164

PSA

56.84

LOGP

1.7209

编号系统

MDL号

MFCD09878608

物化性质

密度

1.197g/cm3

折射率

1.636

合成路线

1450663-24-7

(3R,4R)-tert-butyl 4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

477600-74-1

N-甲基-N-((3R,4R)-4-甲基哌啶-3-基)-7H-吡咯并[2,3-D]嘧啶-4-胺

上游原料

共找到9个上游原料 >

176966-78-2

tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate

1450663-24-7

(3R,4R)-tert-butyl 4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

176966-77-1

tert-butyl (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one-1-carboxylate

(4R,5S)-tert-butyl 5-((tert-butyldiphenylsilyl)oxy)-4-methyl-2-oxopiperidine-1-carboxylate

上游原料

tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate (3R,4R)-tert-butyl 4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate tert-butyl (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one-1-carboxylate (S)-5-羟基哌啶-2酮 6-氨基-7-氮杂嘌呤 (4R,5S)-tert-butyl 5-((tert-butyldiphenylsilyl)oxy)-4-methyl-2-oxopiperidine-1-carboxylate tert-butyl (3S,4R)-3-(tert-butyldiphenylsilyloxy)-4-methyl-piperidine-1-carboxylate