化合物简介
Cytisine, also known as baptitoxine and sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae. It has been used medically to help with smoking cessation. Its molecular structure has some similarity to that of nicotine and it has similar pharmacological effects. Like varenicline, cytisine is a partial agonist of nicotinic acetylcholine receptors (nAChRs). Cytisine has a short half-life of 4.8 hours, and is rapidly eliminated from the body. The use of cytisine for smoking cessation remains relatively unknown outside Eastern Europe.
基本信息
中文名称
金雀花碱
英文名称
cytisine
中文别名
乌乐碱、司巴丁、金链花碱、金莲花碱、金雀儿碱、野靛碱、金雀花硷
英文别名
(-)-Cytisine、CYTISINE、Tsitafat；Lupinidine、Tabex、Cytiton、(1R,5S)-3,4,5,6-Tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one、8H-Pyrido-[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-1,5-methano-、Baptitoxin、Sophorine、Cytitone、Baptitoxine、Laburnin
CAS号
485-35-8
分子式
C11H14N2O
分子量
190.242
精确质量
190.111
PSA
34.03
LOGP
0.8838
编号系统
MDL号
MFCD00136048
物化性质
外观与性状
灰白色至黄褐色的结晶固体
密度
1.24 g/cm3
沸点
218ºC (2 mmHg)
熔点
154-156ºC
闪点
203.6ºC
储存条件
Store at RT
蒸汽压
4.95E-07mmHg at 25°C
安全信息
RTECS号
HA4025000
安全说明
S26-S28-S36/37-S45
危险类别码
R25; R36/37/38
WGK Germany
3
海关编码
2933990090
危险品运输编码
UN 2811
危险类别
6.1(b)
包装等级
III
危险品标志
T
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