化合物简介
Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.
基本信息
中文名称
卡比沙明
英文名称
carbinoxamine
中文别名
2-[(4-氯苯基)(吡啶-2-基)甲氧基]-N,N-二甲基乙胺、氯苯吡醇胺
英文别名
Carbinoxamina、2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine、Rotoxamine、2-((4-Chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethanamine、Carbinoxaminum、Clistin、(+/-)-Carbinoxamine、McN-R 73Z、Allergefon
CAS号
486-16-8
分子式
C16H19ClN2O
分子量
290.788
精确质量
290.119
PSA
25.36
LOGP
3.4026
编号系统
UNII
982A7M02H5
物化性质
密度
1.143g/cm3
沸点
381.1ºC at 760mmHg
闪点
184.3ºC
安全信息
海关编码
2933399090