化合物简介
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
基本信息
中文名称
环氯胍
英文名称
1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
中文别名
英文别名
Cycloguanyl、Cycloguanil、1-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine、Chlorcycloguanil、WR 5473、Chlorguanide triazine、1-(4-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-1,3,5-triazine、1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine、1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine、1-(4-Chlor-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazin-2,4-diyldiamin
CAS号
516-21-2
分子式
C11H14ClN5
分子量
251.715
精确质量
251.094
PSA
75.0
LOGP
2.8669
编号系统
UNII
26RM326WVN
物化性质
密度
1.4g/cm3
沸点
400.7ºC at 760mmHg
闪点
196.1ºC
安全信息
海关编码
2933699090
