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5,6-二氯-1-β-D-呋喃核糖基苯并咪唑

5,6-二氯-1-β-D-呋喃核糖基苯并咪唑

CAS号：53-85-0

英文名：5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole

分子式

C12H12Cl2N2O4

熔点

222-224ºC

密度

1.84 g/cm3

分子量

319.141

沸点

606.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.

基本信息

中文名称

5,6-二氯-1-β-D-呋喃核糖基苯并咪唑

英文名称

5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole

中文别名

5,6-二氯苯并咪唑核糖甙、5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole、二氯苯并咪唑呋喃型核糖苷、5,6-二氯-1-(β-D-呋核亚硝脲)苯并咪唑、5,6-二氯苯并咪唑1-β-D-次黄嘌呤

英文别名

5,6-Dichlorobenzimidazole Riboside、5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside、DRB、5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole

CAS号

53-85-0

分子式

C12H12Cl2N2O4

分子量

319.141

精确质量

318.017

PSA

87.74

LOGP

0.9546

编号系统

UNII

8153319T3Q

物化性质

外观与性状

白色至灰白色结晶固体

密度

1.84 g/cm3

沸点

606.2ºC at 760 mmHg

熔点

222-224ºC

闪点

320.4ºC

折射率

1.749

储存条件

-20ºC

安全信息

WGK Germany

3

合成路线

5,6-dichloro-2-(methylthio)-1-β-D-ribofuranosylbenzimidazole

5,6-dichloro-2-(methylthio)-1-β-D-ribofuranosylbenzimidazole

5,6-二氯-1-β-D-呋喃核糖基苯并咪唑

5,6-二氯-1-β-D-呋喃核糖基苯并咪唑

上游原料

共找到13个上游原料 >

5,6-dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)benzimidazole-2-thione

5,6-dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)benzimidazole-2-thione

5,6-dichloro-2-mercapto-1-(β-D-ribofuranosyl)-benzimidazole

5,6-dichloro-2-mercapto-1-(β-D-ribofuranosyl)-benzimidazole

5,6-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)benzimidazole

5,6-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)benzimidazole

[3,4-bis(benzoyloxy)-5-chlorooxolan-2-yl]methyl benzoate

[3,4-bis(benzoyloxy)-5-chlorooxolan-2-yl]methyl benzoate

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(5,6-dichloro-benzoimidazol-1-yl)-tetrahydro-furan-3-yl ester

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(5,6-dichloro-benzoimidazol-1-yl)-tetrahydro-furan-3-yl ester

1,2,3,5-四-O-乙酰基-β-D-呋喃核糖

1,2,3,5-四-O-乙酰基-β-D-呋喃核糖

上游原料

5,6-dichloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)benzimidazole-2-thione 5,6-dichloro-2-mercapto-1-(β-D-ribofuranosyl)-benzimidazole 5,6-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)benzimidazole [3,4-bis(benzoyloxy)-5-chlorooxolan-2-yl]methyl benzoate Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(5,6-dichloro-benzoimidazol-1-yl)-tetrahydro-furan-3-yl ester 1,2,3,5-四-O-乙酰基-β-D-呋喃核糖 5,6-二氯苯并咪唑-2-硫醇 1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖鸟苷 5-甲基苯并咪唑 5,6-dichloro-2-(methylthio)-1-β-D-ribofuranosylbenzimidazole 2,3,5-tri-O-acetyl-α-D-ribofuranosyl chloride 4,5-二氯邻苯二胺