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去氧孕烯

去氧孕烯

CAS号:54024-22-5
英文名:desogestrel
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化合物简介
A progestogen with low androgenic potency.
基本信息
编号系统
物化性质
生产方法及用途
生产方法
化合物(Ⅰ)先氧化11位的羟基为酮后,再进行Wittig反应,然后脱缩酮,得到化合物(Ⅲ)。(Ⅲ)和乙二硫醇反应,在3位形成硫缩酮,接着硼氢化钠还原17位羰基为羟基,再在液氨中和钠作用,脱去3位的硫缩酮,得到化合物(Ⅶ)。把17位的羟基重新氧化为羰基,最后和乙炔钾反应,得到去氧孕烯。
用途
为强效排卵抑制剂,尚能改变宫颈粘液稠度、抑制子宫内膜发育
上游原料
(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dithiolan]-17-ol 17β-(tert-butyldimethylsiloxy)-13-ethyl-11-methylene-3-methoxygona-1,3,5(10)-triene (17beta)-13-乙基-17-羟基-11-亚甲基-4-雌烯-3-酮 3,3-ethylenedithio-18a-homo-estr-4-ene-11α,17β-diol 11a-羟基-18-甲基雌甾-4-烯-3,17-二酮 乙炔 11,11-Methylen-18-methyl-Δ4-oestren-3,17-dion 13-ethyl-gona-4-ene-11α,17β-diol 17β-(tert-butyldimethylsiloxy)-11-carbomethoxy-13-ethyl-3-methoxygona-1,3,5(10),9(11)-tetraene 18a-homo-estr-4-ene-11,17-dione 13-乙基-11-亚甲基-4-雌烯-17-酮 17,17-((2,2-dimethyl)propane-1,3-dioxy)-18a-homo-estr-4-en-11-one 3,3:17,17-bis[1,2-ethenediylbis(oxy)]-11β-hydroxyestr-5-en-18-oic acid γ-lactone 11-methylene-17-<(2,2-dimethyl)propane-1,3-dioxy>-18a-homo-estr-4-ene 17β-(tert-butyldimethylsiloxy)-13-ethyl-11-(hydroxymethyl)-3-methoxygona-1,3,5(10),9(11)-tetraene 11-carbomethoxy-13-ethyl-3-methoxygona-1,3,5(10),9(11)-tetraen-17β-ol (+)-(1S,3aS,4S,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxy-4-(2-(3-methoxyphenyl)ethyl)indane (+)-(1S,3aS,7aS)-3a,4,7,7a-tetrahydro-1-(tert-butyldimethylsiloxy)-6-carbomethoxy-7a-ethyl-5-hydroxyindane 13-ethyl-11β-hydroxygon-5-ene-3,17-dione cyclic bis(1,2-ethanediyl acetal) (+)-13β-ethyl-11-methylenegona-4-en-17β-ol (+)-(1S,3aS,7aS)-hexahydro-1-(tert-butyldimethylsiloxy)-7a-ethyl-5-indanone D-13β-Ethyl-3,3-ethylenedithio-11-methylenegon-4-ene-17α-ol D-13β-Ethyl-11β-hydroxy-11α-methylgon-5-ene-3,11-dione-3,17-diethylene ketal 18-甲基-11-亚甲基雌甾-4-烯-3,17-二酮 13-ethyl-11-methylenegon-5-ene-3,17-dione cyclic bis(1,2-ethanediyl acetal) 13-ethyl-11-methylenegon-4-ene-3,17-dione cyclic 3-(1,2-ethanediyl dithioacetal) D-13β-Ethyl-11-methylenegon-4-en-17α-ol 3-methoxy-18a-homo-estra-2,5(10)-diene-11α,17β-diol 11α,17β-Dihydroxy-18a-homo-estr-4-en-3-one 13β-ethyl-gona-5-ene-3,11,17-trione-3,17-diethylene ketal (+)-13β-ethyl-3,3-ethylenedithio-11-methylenegona-4-en-17β-ol 18a-homoestr-5-ene-3,11,17-trione cyclic 3,17-bis(1,2-ethanediyl acetal)
下游产品