百科

司骨化醇

CAS号：55721-11-4

英文名：(24R)-24,25-dihydroxycalciol

分子式

C27H44O3

熔点

63-65ºC

密度

1.06 g/cm3

分子量

416.636

沸点

571.1ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

A metabolite of Vitamin D, a possibly anti-inflammatory steroid.

基本信息

中文名称

司骨化醇

英文名称

(24R)-24,25-dihydroxycalciol

中文别名

英文别名

k-dr、osteod、Secalciferol

CAS号

55721-11-4

分子式

C27H44O3

分子量

416.636

精确质量

416.329

PSA

60.69

LOGP

5.7047

编号系统

UNII

460029IUDA

物化性质

密度

1.06 g/cm3

沸点

571.1ºC at 760 mmHg

熔点

63-65ºC

闪点

241.5ºC

折射率

1.547

储存条件

Amber Vial, -20ºC Freezer, Under Inert Atmosphere

安全信息

安全说明

S28-S36/37-S45

危险类别码

R28

危险品运输编码

UN 2811

危险品标志

T+

危险性描述

H301 + H311; H330; H372

信号词

Danger

危险标志

GHS06, GHS08

危险性防范说明

P260; P280; P284; P301 + P310; P310

合成路线

1243679-37-9

上游原料

5-Cholesten-3β,24,25-triol-3β,24-diacetat

136463-16-6

(3R,3aR,5aR,5bR,8S,9aS,17aS,17bR)-3a,5b-dimethyl-11,16-dioxo-3-((S)-1-(phenylsulfonyl)propan-2-yl)-2,3,3a,4,5,5a,5b,6,7,8,9,11,16,17b-tetradecahydro-1H-9a,17a-ethenobenzo[c]cyclopenta[h]phthalazino[2,3-a]cinnolin-8-yl acetate

113278-73-2

Toluene-4-sulfonic acid (R)-2-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-4-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

113278-72-1

(R)-2-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-4-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)butan-1-ol

77517-57-8

(2S)-2-((3S,9S,10R,13R,14R,17R)-10,13-dimethyl-3-((tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)propan-1-ol

上游原料

ethyl (R)-2-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-4-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)butanoate 5-Cholesten-3β,24,25-triol-3β,24-diacetat (3R,3aR,5aR,5bR,8S,9aS,17aS,17bR)-3a,5b-dimethyl-11,16-dioxo-3-((S)-1-(phenylsulfonyl)propan-2-yl)-2,3,3a,4,5,5a,5b,6,7,8,9,11,16,17b-tetradecahydro-1H-9a,17a-ethenobenzo[c]cyclopenta[h]phthalazino[2,3-a]cinnolin-8-yl acetate Toluene-4-sulfonic acid (R)-2-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-4-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester (R)-2-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-4-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)butan-1-ol (2S)-2-((3S,9S,10R,13R,14R,17R)-10,13-dimethyl-3-((tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)propan-1-ol (3R,3aR,5aR,5bR,8S,9aS,17aS,17bR)-3-((S)-1-hydroxypropan-2-yl)-3a,5b-dimethyl-11,16-dioxo-2,3,3a,4,5,5a,5b,6,7,8,9,11,16,17b-tetradecahydro-1H-9a,17a-ethenobenzo[c]cyclopenta[h]phthalazino[2,3-a]cinnolin-8-yl acetate (3β,5Z,7E,24R)-3-[(tert-butyldimethylsilyl)oxy]-9,10-secocholesta-5,7,10(19)-triene-24,25-diol cyclic 24,25-(1-methylethylidene acetal) ethyl 6β-methoxy-3α,5α-cyclopregnan-21-oate 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone (24R)-3β-(2H-tetrahydropyran-2-yloxy)cholesta-5,7-diene-24,25-diol 25-hydroxycholesta-5,7-dien-3β,24-diyl diacetate (6RS,24R)-6-methoxy-9,10-seco-3,5-cyclocholesta-7,10(19)-dien-24,25-diol (24R,6Z)-(25-hydroxy-9,10-secocholesta-5(10),6,8(9)-trien-3β,24-diyl) diacetate 22-bromo-3β-tetrahydropyranyloxy-23,24-dinorchola-5,7-diene (3R,6R)-2-hydroxy-2-methyl-6-((1R,3aR,7aR)-7a-methyl-4-oxooctahydro-1H-inden-1-yl)heptan-3-yl acetate 3β-tetrahydropyranyloxy-23,24-dinorchola-5,7-dien-22-ol p-toluenesulfonate 3-acetoxy-1',4'-dioxo-1',4'-dihydro-5,8-etheno-phthalazino[2',3':6,7](6,7-diaza-23,24-dinor-cholan)-21-al (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-4-((R)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)butan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate (1R,3aR,4S,7aR)-1-[(1R,4R)-4,5-dihydroxy-1,5-dimethylhexyl]-7a-methyl-octahydro-1H-inden-4-ol (24R)-22ξ-phenylsulfonyl-3β-(2H-tetrahydropyran-2-yloxy)cholesta-5,7-diene-24,25-diol (R)-5-((R)-3-((1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)butyl)-2,2,4,4-tetramethyl-1,3-dioxolane (2R)-2,3-dihydroxy-3-methylbutan-1-yl p-toluenesulfonate 3-acetate of (24R)-24,25-dihydroxyvitamin D3 22-phenylsulfonyl-3β-(2H-tetrahydropyran-2-yloxy)-23,24-bisnorchola-5,7-diene (24R)-de-A,B-24,25-dihydroxycholestan-8-one cyclic 24,25-(1-methylethylidene acetal)