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罗红霉素

罗红霉素

CAS号：56092-81-0

英文名：ionomycin

分子式

C41H72O9

熔点

密度

1.072 g/cm3

分子量

709.005

沸点

817.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

离子霉素（英语：Ionomycin）是一种由细菌 Streptomyces conglobatus 产生的离子载体。它能用来提高细胞内的钙离子（Ca2+）水平，因而用于研究Ca2+ 的跨膜机制。离子霉素也常与PMA联用来刺激细胞产生一些胞间产物，比如一些细胞因子，如干扰素、穿孔素、IL-2和IL-4。这些细胞因子在炎症反应中有重要作用。

基本信息

中文名称

罗红霉素

英文名称

ionomycin

中文别名

离子霉素

英文别名

Ionomycin,Free Acid,from Streptomyces conglbatus、Ionomycinefreeacid、Ionomycin,Free Acid,Streptomyces conglobatus、Ionomycin free acid,(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2\'R,5S,5\'S)-octahydro-5\'-[(1R)-1-hydroxyethyl]-2,5\'-dimethyl[2,2\'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid、IONOMYCIN,STREPTOMYCES CONGLOBATUS、Ionomycin from Streptomyces conglobatus、IONOMYCIN

CAS号

56092-81-0

分子式

C41H72O9

分子量

709.005

精确质量

708.518

PSA

153.75

LOGP

7.7996

编号系统

EINECS号

611-356-7

物化性质

外观与性状

淡黄色油状

密度

1.072 g/cm3

沸点

817.2ºC at 760 mmHg

闪点

235.2ºC

折射率

1.512

储存条件

-20ºC

安全信息

安全说明

36-36/37/39-27-26

危险类别码

R22

海关编码

2941500000

危险品标志

Xn

合成路线

ionomycin methyl ester

ionomycin methyl ester

罗红霉素

上游原料

共找到90个上游原料 >

((S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl)triphenylphosphonium iodide

((S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl)triphenylphosphonium iodide

[2R,3R,4S,4(2S,4S)]-3-((triisopropylsilyl)oxy)-4-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-1-ol

[2R,3R,4S,4(2S,4S)]-3-((triisopropylsilyl)oxy)-4-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-1-ol

(R)-1-{(2R,5S,2'S,5'R)-5'-[(4S,5S,6R)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl]-5,2'-dimethyl-octahydro-[2,2']bifuranyl-5-yl}-ethanol

(R)-1-{(2R,5S,2'S,5'R)-5'-[(4S,5S,6R)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl]-5,2'-dimethyl-octahydro-[2,2']bifuranyl-5-yl}-ethanol

(S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl methanesulfonate

(S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl methanesulfonate

(4R,5S,6S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-6-((Z)-(S)-5-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,5S)-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-furan-2-yl}-hex-1-enyl)-2,2,5-trimethyl-[1,3]dioxane

(4R,5S,6S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-6-((Z)-(S)-5-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,5S)-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-furan-2-yl}-hex-1-enyl)-2,2,5-trimethyl-[1,3]dioxane

(2'S,3'R,4R,5S)-3-(2'-ethenyl-3'-hydroxy-4'-methyl-5'-(benzyloxy)pentanoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-one

(2'S,3'R,4R,5S)-3-(2'-ethenyl-3'-hydroxy-4'-methyl-5'-(benzyloxy)pentanoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-one

上游原料

((S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl)triphenylphosphonium iodide [2R,3R,4S,4(2S,4S)]-3-((triisopropylsilyl)oxy)-4-[2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-1-ol (R)-1-{(2R,5S,2'S,5'R)-5'-[(4S,5S,6R)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-ylmethyl]-5,2'-dimethyl-octahydro-[2,2']bifuranyl-5-yl}-ethanol (S)-4-((tert-butyldimethylsilyl)oxy)-4-((2R,5S)-5-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyltetrahydrofuran-2-yl)pentyl methanesulfonate (4R,5S,6S)-4-((R)-2-Benzyloxy-1-methyl-ethyl)-6-((Z)-(S)-5-(tert-butyl-dimethyl-silanyloxy)-5-{(2R,5S)-5-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-tetrahydro-furan-2-yl}-hex-1-enyl)-2,2,5-trimethyl-[1,3]dioxane (2'S,3'R,4R,5S)-3-(2'-ethenyl-3'-hydroxy-4'-methyl-5'-(benzyloxy)pentanoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-one 乙酸香叶酯 (2R,3R,4S)-1-(benzyloxy)-2,4-dimethyl-3-hydroxy-5-hexene (3R,4S)-1-(benzyloxy)-3-hydroxy-4-(hydroxymethyl)-2-methyl-5-hexene (E,E)-8-acetoxy-2,6-dimethyl-2,6-octadien-1-ol (2R,3S)-3-(tert-butyldimethylsilyloxy)-2-methylbutanal [2S,2(2R),5R,5(1S)]-5-[3-benzenesulfonyl-1-(trimethylsilyloxy)-1-methyl-propyl]-2-(1-(t-butyldimethylsiloxy)-ethyl)-2-methyl-tetrahydrofuran ionomycin methyl ester acetic acid,8-bromo-3,7-dimethylocta-2,6-dien-1-ol (1S,2R,6R,4Z)-5-(3'-(benzyloxy)propyl)-1,2,4-trimethyl-3,9-dioxabicyclo[4.2.1]non-4-ene (1'R,4R,5S,6R)-4-(2'-(benzyloxy)-1'-methylethyl)-6-(hydroxymethyl)-2,2,5-trimethyl-1,3-dioxane (1''S,1'R,2R,5S)-5-(1'-hydroxyethyl)-5-methyl-2-(1''-hydroxy-1''-methyl-4''-(benzyloxy)butyl)tetrahydrofuran [2S,2(2R,5S,5(1R)),5R,7S,8S,9R,10R]-7-benzoyloxy-5-hydroxy-9-triisopropylsilyloxy-8,10-dimethyl-2-[5-methyl-5-(1-(t-butyldimethylsilyloxy)-ethyl)tetrahydrofuran-2-yl]-2-trimethylsilyloxy-11-trityloxy-undecane [2R,3R,4S,4(4R,5R)]-4-[5-methyl-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-1,3-diol [1S,1(2S,5S,2'R,5'S,5'(1R)),2S,3R,4R]-benzoic acid 1-[2,5'-dimethyl-5'-(1-t-butyldimethylsilyloxy-ethyl)-octahydro-[2,2']bifuranyl-5-ylmethyl]-5-hydroxy-2,4-dimethyl-3-triisopropylsilyloxy-pentyl ester (+)-(4S)-3-(5-(benzyloxy)-(2S)-((2R,5S)-5-methyl-5-((1R)-1-hydroxyethyl)tetrahydrofuranyl)pentanoyl)-4-isopropyl-1,3-oxazolidin-2-one [2S,2(2R,5S,5(1R)),7S,8S,9R,10R]-9-triisopropylsilyloxy-7-(4-methoxy-benzyloxy)-8,10-dimethyl-2-[5-methyl-5-(1-(t-butyldimethylsilyloxy)-ethyl)tetrahydrofuran-2-yl]-2-trimethylsilyloxy-11-trityloxy-undecan-5-one [4R,6S,6(4S,5R)]-4-methyl-6-(5-methyl-2-thioxo-[1,3]dioxan-4-yl)-heptanoic acid methyl ester [2S,4S,4(4S,5R)]-4-[5-methyl-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-1-ol [3S,4S,5R,6R]-5-((triisopropylsilyl)oxy)-3-(4-methoxy-benzyloxy)-4,6-dimethyl-7-(triphenylmethyl)oxy-heptan-1-ol [2R,3R,4S,5S]-3-((triisopropylsilyl)oxy)-5-(4-methoxy-benzyloxy)-2,4-dimethylheptane-1,7-diol (1''R,1'R,2R,5S)-5-(1'-(tert-butyldimethylsiloxy)ethyl)-5-methyl-2-(1''-(tert-butyldimethylsiloxy)-1''-methyl-4''-(benzyloxy)butyl)tetrahydrofuran (4R,6E)-2,4-dimethyl-7-phenyl-6-hepten-1-ol (Z)-(S)-6-[(4S,5S,6R)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-2-[(2R,5S)-5-((R)-1-hydroxy-ethyl)-5-methyl-tetrahydro-furan-2-yl]-hex-5-en-2-ol ((R)-1-((2R,2'S,5S,5'S)-5'-(((4S,5S,6R)-6-((R)-1-(benzyloxy)propan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)methyl)-2',5-dimethyloctahydro-[2,2'-bifuran]-5-yl)ethoxy)(tert-butyl)dimethylsilane (2R,3R,4S)-1-(benzyloxy)-2,4-dimethyl-6-(diphenyl-tert-butylsiloxy)-2,4-hexanediol (3R,4S)-1-(benzyloxy)-3-hydroxy-2-methyl-4-((((4-methylphenyl)sulfonyl)oxy)methyl)-5-hexene [2R,3R,4R,5R,6R]-2,4,6-trimethyl-5-(4-methoxybenzyloxy)-3-((t-butyldimethylsilyl)oxy)-heptane-1,7-diol [3S,4S,5R,6R]-5-((trisopropylsilyl)oxy)-3-(4-methoxy-benzyloxy)-4,6-dimethyl-7-(triphenylmethyl)oxy-heptanal [4R,6S,8S]-4,6,8-trimethyl-9-oxo-decanoic acid methyl ester methyl (4R,6S,8S)-9-hydroxy-4,6,8-trimethylnonanoate (1'R,4R,5S)-4-(2'-(benzyloxy)-1'-methylethyl)-6-((diphenyl-tert-butylsiloxy)methyl)-2,2,5-trimethyl-1,3-dioxane [2R,3S,6E]-toluene-4-sulfonic acid-9-benzenesulfonyl-2-(t-butyldimethylsiloxy)-3-hydroxy-3,7-dimethyl-non-6-enyl ester (1'R,2R,5S)-5-(1'-acetoxyethyl)-5-methyl-2-(1''-oxo-4''-(benzyloxy)butyl)tetrahydrofuran benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester [1S,1(2S,5S,2'R,5'S,5'(1R)),2S,3R,4R]-benzoic acid 1-[2,5'-dimethyl-5'-(1-t-butyldimethylsilyloxy-ethyl)-octahydro-[2,2']bifuranyl-5-ylmethyl]-2,4-dimethyl-3-triisopropylsilyloxy-5-trityloxy-pentyl ester benzoic acid 3-hydroxy-1-[5'-(1-hydroxy-ethyl)-2,5'-dimethyl-octahydro-[2,2']bifuranyl-5-yl-methyl]-20-methoxycarbonyl-2,4,8,10,14,16,18-heptamethyl-11,13-dioxo-eicos-5-enyl ester [2S,2(2R,5S,5(1R)),7S,8S,9R,10R]-7-hydroxy-9-triisopropylsilyloxy-8,10-dimethyl-2-[5-methyl-5-(1-(t-butyldimethylsilyloxy)-ethyl)tetrahydrofuran-2-yl]-2-trimethylsilyloxy-11-trityloxy-undecan-5-one [4S,6S,6(4S,5R)]-6-[2-(4-methoxyphenyl)-5-methyl-[1,3]dioxan-4-yl]-4-methyl-hept-2-enoic acid methyl ester [4R,4(1R),1(4R,5R),5R]-5-methyl-4-[1-(5-methyl-2-(4-methoxyphenyl)-[1,3]dioxan-4-yl)-ethyl]-[1,3]dioxane-2-thione