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Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺

Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺

CAS号：566939-85-3

英文名：6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

分子式

C18H17N3O2

熔点

密度

分子量

307.346

沸点

溶解度

信号词

危险品标志

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化合物简介

Orteronel (TAK-700) is a non-steroidal antiandrogen that was being developed for the treatment of cancer by Takeda Pharmaceutical Company in conjunction with Millennium Pharmaceuticals. It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result.

基本信息

中文名称

Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺

英文名称

6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

中文别名

英文别名

TAK-700-Orteronel、TAK 700、Orteronel

CAS号

566939-85-3

分子式

C18H17N3O2

分子量

307.346

精确质量

307.132

PSA

67.15

LOGP

2.4264

合成路线

6-[(1S)-1,3-dihydroxy-1-(1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide

6-[(1S)-1,3-dihydroxy-1-(1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide

Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺

Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺

上游原料

共找到20个上游原料 >

6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺

6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺

N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

6-bromo-N,N-diisopropyl-2-naphthamide

6-bromo-N,N-diisopropyl-2-naphthamide

6-溴-N-甲基-2-萘甲酰胺

6-溴-N-甲基-2-萘甲酰胺

N-Methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

N-Methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide

6-溴-2-萘甲酸

6-溴-2-萘甲酸

上游原料

6-(6,7-二氢-7-羟基-5H-吡咯并[1,2-c]咪唑-7-基)-n-甲基-2-萘羧酰胺 N,N-diisopropyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide 6-bromo-N,N-diisopropyl-2-naphthamide 6-溴-N-甲基-2-萘甲酰胺 N-Methyl-6-[(1-trityl-1H-imidazol-4-yl)carbonyl]-2-naphthamide 6-溴-2-萘甲酸 5H-吡咯并[1,2-c]咪唑-7(6H)-酮 ethyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-tosyl-1H-imidazol-4-yl)propanoate N,N-diisopropyl-6-[1-hydroxy-1-(1-trityl-1H-imidazol-4-yl)methyl]-2-naphthamide 6-[(1S)-1,3-dihydroxy-1-(1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N,N-diisopropyl-2-naphthamide 6-(hydroxy(1-tosyl-1H-imidazol-4-yl)methyl)-N-methyl-2-naphthamide 3-bromo-1-(1H-imidazol-4-yl)-1-propanone hydrobromide 1-(1H-imidazol-4-yl)prop-2-en-1-one 6-[hydroxy(1-trityl-1H-imidazol-4-yl)methyl]-N-methyl-2-naphthamide 6-bromonaphthalene-2-carbonyl chloride ethyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl)-3-(1-trityl-1H-imidazol-4-yl)propanoate 6-[(1S)-1,3-Dihydroxy-1-(1-trityl-1H-imidazol-4-yl)propyl]-N-meth yl-2-naphthamide 6-[(1S)-1,3-dihydroxy-1-(1-tosyl-1H-imidazol-4-yl)propyl]-N-methyl-2-naphthamide