百科

美登醇

美登醇

CAS号：57103-68-1

英文名：MAYTANSINOL

分子式

C28H37ClN2O8

熔点

密度

1.34g/cm3

分子量

565.055

沸点

835.8ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Maytansinol is used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.

基本信息

中文名称

美登醇

英文名称

MAYTANSINOL

中文别名

英文别名

Maytansinol (7)、O3-de-(N-acetyl-N-methyl-L-alanyl)-maytansine、(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84,12c-dihydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r\'H,86c\'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

CAS号

57103-68-1

分子式

C28H37ClN2O8

分子量

565.055

精确质量

564.224

PSA

130.09

LOGP

3.5105

物化性质

密度

1.34g/cm3

沸点

835.8ºC at 760mmHg

闪点

459.3ºC

折射率

1.607

合成路线

共找到4条合成路线 >

N(2')-去乙酰基-N(2')-(2-甲基-1-氧代丙基)-美登素

N(2')-去乙酰基-N(2')-(2-甲基-1-氧代丙基)-美登素

美登醇

上游原料

共找到8个上游原料 >

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate

安丝菌素 P 3

安丝菌素 P 3

(2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile

(2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one

(1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione

(1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione

N(2')-去乙酰基-N(2')-(2-甲基-1-氧代丙基)-美登素

N(2')-去乙酰基-N(2')-(2-甲基-1-氧代丙基)-美登素

下游产品

共找到4个下游商品 >

安丝菌素P-3

安丝菌素P-3

DM1 SMCC

安丝菌素 P 3

安丝菌素 P 3

DM 1

上游原料

(5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-5,12-dimethoxy-2,6,8,16-tetramethyl-3-oxospiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-9-yl carbamate 安丝菌素 P 3 (2Z,4E)-2-formyl-5-methoxypenta-2,4-dienenitrile (5S,6E,8S,9S,12R,13E,15E)-5-((tert-butyldimethylsilyl)oxy)-6-chloro-9-hydroxy-5,12-dimethoxy-2,6,8,16-tetramethylspiro[2-aza-1(1,3)-benzenacycloheptadecaphanene-11,2'-[1,3]dithiane]-6,13,15-trien-3-one (1<sup>4</sup>S,1<sup>6</sup>S,2R,3E,5E,12S,13E,15S)-8<sup>4</sup>-chloro-12-hydroxy-1<sup>4</sup>,8<sup>5</sup>,2-trimethoxy-6,9,13,15-tetramethyl-9-aza-1(4,6)-oxazinana-8(1,3)-benzenacyclopentadecaphane-3,5,13-triene-1<sup>2</sup>,10-dione N(2')-去乙酰基-N(2')-(2-甲基-1-氧代丙基)-美登素 3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol (-)-maytansinol

下游产品

安丝菌素P-3 DM1 SMCC 安丝菌素 P 3 DM 1