化合物简介
trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene. Benzo[a]pyrene, a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen.
基本信息
中文名称
反式-7,8-二羟基-7,8-二氢-苯并(a)芘
英文名称
(9S,10S)-9,10-Dihydrobenzo[pqr]tetraphene-9,10-diol
中文别名
英文别名
(+/-)-benzo<a>pyrene-trans-7,8-dihydrodiol、(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo<a>pyrene、trans-7,8-dihydro-7,8-dihydroxybenz[a]pyrene、(+/-)-trans-benzo[a]pyrene-7,8-dihydrodiol
CAS号
57404-88-3
分子式
C20H14O2
分子量
286.324
精确质量
286.099
PSA
40.46
LOGP
4.0051
物化性质
密度
1.46g/cm3
沸点
553.3ºC at 760mmHg
闪点
268.6ºC
折射率
1.911
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