化合物简介
1-(-1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.
基本信息
中文名称
1-(1-萘基)对二氮已环
英文名称
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
中文别名
1-(1-萘)哌嗪盐酸盐
英文别名
NPPI、1-NAPHTHALENE-1-YL-PIPERAZINE HCL、naphthylpiperazine、1-NAPHTHALEN-1-YL-PIPERAZINE HYDROCHLORIDE
CAS号
57536-86-4
分子式
C14H17ClN2
分子量
248.751
精确质量
248.108
PSA
15.27
LOGP
3.4452
物化性质
外观与性状
白色至黄褐色的粉末
密度
1.106 g/cm3
沸点
391.9ºC at 760 mmHg
熔点
280°C (dec.)
闪点
188.9ºC
折射率
1.622
安全信息
安全说明
S26-S36/37/39
危险类别码
R36/37/38
WGK Germany
3
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