百科

丁苯那嗪

CAS号：58-46-8

英文名：9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one

分子式

C19H27NO3

熔点

128-130ºC

密度

1.12

分子量

317.423

沸点

448.9ºC at 760mmHg

溶解度

信号词

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化合物简介

Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders. It is marketed under the trade names Nitoman in Canada and Xenazine in New Zealand and some parts of Europe, and is available as Xenazine in the United States as an orphan drug. On August 15, 2008, the U.S. Food and Drug Administration approved the use of tetrabenazine to treat chorea associated with Huntington's disease. Although other drugs had been used \"off label,\" tetrabenazine was the first approved treatment for Huntington's disease in the U.S. The compound has been known since the 1950s.

基本信息

中文名称

丁苯那嗪

英文名称

9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one

中文别名

丁苯喹嗪、顺式-9,10-二甲氧基-1,3,4,6,7,11B-六氢-3-异丁基-2H-苯并[A]喹嗪-2-酮、3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-苯并[a]喹啉-2-酮

英文别名

2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-、TETRABENAZINE、Tetrabenazine,(3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one、Nitoman、Rubigen、Ro 1-9569

CAS号

58-46-8

分子式

C19H27NO3

分子量

317.423

精确质量

317.199

PSA

38.77

LOGP

3.176