蛋氨酸-脑啡呔

蛋氨酸-脑啡呔

CAS号：58569-55-4

英文名：2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid

分子式

C27H35N5O7S

熔点

密度

1.324 g/cm3

分子量

573.661

沸点

1052.9ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration. It is one of the two forms of enkephalin, the other being leu-enkephalin. The enkephalins are considered to be the primary endogenous ligands of the δ-opioid receptor, due to their high potency and selectivity for the site over the other endogenous opioids.

基本信息

中文名称

蛋氨酸-脑啡呔

英文名称

2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid

中文别名

[MET5]脑啡肽、蛋氨酸脑啡肽

英文别名

MET-enkephalin、Lupex、Opioid growth factor、H-Tyr-Gly-Gly-Phe-Met-OH、Tyr-Gly-Gly-Phe-Met-OH、TYR-GLY-GLY-PHE-MET、[Met5]-enkephalin、1-5-Adrenorphin (human)、H-Tyr(1)-Gly(2)-Gly(3)-Phe(4)-Met(5)-OH、Methionine enkephalin、ENKEPHALIN,METHIONINE

CAS号

58569-55-4

分子式

C27H35N5O7S

分子量

573.661

精确质量

573.226

PSA

225.25

LOGP

1.8083

编号系统

UNII

9JEZ9OD3AS

物化性质

外观与性状

白色冻干的固体

密度

1.324 g/cm3

沸点

1052.9ºC at 760 mmHg

闪点

590.6ºC

折射率

1.608

储存条件

-20ºC

安全信息

安全说明

S22-S24/25

WGK Germany

3

生产方法及用途

生产方法

以L-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸为原料,先将氨基酸中有侧链的氨基酸的侧链按其特性分别用保护剂保护后,在多肽缩合剂存在下进行缩合反应,然后除去保护剂纯化制得。

用途

用于生化研究,神经生物学研究。

合成路线

共找到1条合成路线 >

(5S,14S,17S)-14-benzyl-5-(4-hydroxybenzyl)-17-(2-(methylthio)ethyl)-1-(3-nitro-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,6,9,12,15-pentaoxo-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid

(5S,14S,17S)-14-benzyl-5-(4-hydroxybenzyl)-17-(2-(methylthio)ethyl)-1-(3-nitro-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,6,9,12,15-pentaoxo-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid

4-羟基-3-硝基苄醇

4-羟基-3-硝基苄醇

蛋氨酸-脑啡呔

蛋氨酸-脑啡呔

上游原料

共找到62个上游原料 >

(2S)-2-(diphenylphosphorylamino)-3-phenylpropanoic acid

(2S)-2-(diphenylphosphorylamino)-3-phenylpropanoic acid

BOC-L-苯丙氨酸

BOC-L-苯丙氨酸

1,2,4,5-tetrahydro-1,3-dimethyl-3H-3-benzazepin-2-one

1,2,4,5-tetrahydro-1,3-dimethyl-3H-3-benzazepin-2-one

(5S,14S,17S)-14-benzyl-5-(4-hydroxybenzyl)-17-(2-(methylthio)ethyl)-1-(3-nitro-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,6,9,12,15-pentaoxo-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid

(5S,14S,17S)-14-benzyl-5-(4-hydroxybenzyl)-17-(2-(methylthio)ethyl)-1-(3-nitro-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,6,9,12,15-pentaoxo-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid

N-(diphenylphosphinoyl)phenylalanylmethionine methyl ester

N-(diphenylphosphinoyl)phenylalanylmethionine methyl ester

N-苄氧羰基-L-苯丙氨酸

N-苄氧羰基-L-苯丙氨酸

下游产品

共找到1个下游商品 >

BOC-MET-ENKEPHALIN

BOC-MET-ENKEPHALIN

上游原料

(2S)-2-(diphenylphosphorylamino)-3-phenylpropanoic acid BOC-L-苯丙氨酸 1,2,4,5-tetrahydro-1,3-dimethyl-3H-3-benzazepin-2-one (5S,14S,17S)-14-benzyl-5-(4-hydroxybenzyl)-17-(2-(methylthio)ethyl)-1-(3-nitro-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3,6,9,12,15-pentaoxo-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid N-(diphenylphosphinoyl)phenylalanylmethionine methyl ester N-苄氧羰基-L-苯丙氨酸 N-(diphenylphosphinoyl)glycylglycylphenylalanylmethionine methyl ester N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester L-Methionine, N-L-phenylalanyl-, 1,1-dimethylethyl ester Boc-Tyr-Gly-N3 H-Gly-Phe-Met-OBut glycylphenylalanylmethionine methyl ester hydrochloride Boc-Tyr-Gly-NHNH2 Z-Tyr(Bzl)-Gly-N2H3 N-(diphenylphosphinoyl)tyrosine (S)-diphenylphosphinic (S)-2-((diphenylphosphoryl)amino)-3-(4-hydroxyphenyl)propanoic anhydride Boc-Phe-Hcy(Bzl)-OBzl N-(tert-butyloxycarbonyl)glycyl-L-phenylalanyl-L-methionine methyl ester Boc-L-酪氨酸 Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime BOC-L-苯胺-4-硝基苯酯 N-tert-butoxycarbonylglycylglycylphenylalanylmethionine N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine methyl ester benzyl (S)-1-(tert-butoxycarbonyl)-3-(methylthio)propylcarbamate N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine N-(diphenylphosphinoyl)glycylphenylalanylmethionine methyl ester (S,S)-2-(2-氨基-3-苯基-丙酰基氨基)-4-甲基磺酰基-丁酸甲酯 methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate N-{[(2-甲基-2-丙基)氧基]羰基}苯丙氨酰蛋氨酸甲酯 Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met-OMe 蛋氨酸 (蛋氨酰(O)5)-脑啡肽 Z-Gly-Phe-Met-OBut hydrochloride of methyl ester of L-phenylalanyl-L-methionine methyl 2-[[3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]acetate Boc-Phe-O-COO-isoBu L-酪氨酸甲酯盐酸盐 Z-Phe-Met-OBut BOC-MET-ENKEPHALIN-T-BUTYL ESTER Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl N,O-bis(diphenylphosphinoyl)tyrosine methyl ester Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine L-phenylalanyl-L-methionine hydrochloride N-{[(2-甲基-2-丙基)氧基]羰基}-L-苯丙氨酰-L-蛋氨酸 BOC-MET-ENKEPHALIN tert-butyl (2S)-2-amino-4-methylsulfanylbutanoate

下游产品

BOC-MET-ENKEPHALIN