百科

西奈芬净

CAS号：58944-73-3

英文名：sinefungin

分子式

C15H23N7O5

熔点

密度

1.91g/cm3

分子量

381.387

沸点

783.2ºC at 760 mmHg

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

Sinefungin is a natural nucleoside analog of S-adenosylmethionine and inhibits Streptococcus pneumoniae biofilm growth. Its derivatives can be used as inhibitors and structure probes for human protein lysine methyltransferase SETD2.

基本信息

中文名称

西奈芬净

英文名称

sinefungin

中文别名

英文别名

SINEFUNGIN

CAS号

58944-73-3

分子式

C15H23N7O5

分子量

381.387

精确质量

381.176

PSA

208.65

LOGP

-0.081

编号系统

UNII

W2U467CIIL

物化性质

密度

1.91g/cm3

沸点

783.2ºC at 760 mmHg

闪点

427.5ºC

折射率

1.831

储存条件

2-8ºC

安全信息

危险品标志

合成路线

124288-94-4

(2S,5S)-5-amino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-(4-methylphenylsulfonamido)hexanoic acid compound with 2,2,2-trifluoroacetic acid (1:1)

上游原料

N5-benzyloxycarbonyl-N2-(toluene-4-sulfonyl)-L-ornithine

18055-47-5

N-trimethylsilyl-N-(9-trimethylsilylpurin-6-yl)benzamide

124288-73-9

1,1-dimethylethyl (S)-2-(((4-methylphenyl)sulfonyl)-amino)-5-(((phenylmethoxy)carbonyl)amino)pentanoate

124288-78-4

1,1-dimethylethyl [methyl-6-hydroximino-5,6,7,8,9-pentadeoxy-9(S)-[[(4-methylphenyl)sulfonyl]amino]-2,3-O-(1-methylethylidene)-β-D-ribo-dec-5-enofuranosid]uronates

87884-32-0

9-(methyl 6(S),9(S)-(((tert-butyloxy)carbonyl)amino)-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-decafuranosyluronate)adenine

124288-77-3

1,1-dimethylethyl [methyl-6-nitro-5,6,7,8,9,-pentadeoxy-9(S)-[[(4-methylphenyl)sulfonyl]amino]-2,3-O-(1-methyl-ethylidene)-β-D-ribo-dec-5-enofuranosid]uronates

上游原料

N5-benzyloxycarbonyl-N2-(toluene-4-sulfonyl)-L-ornithine N-trimethylsilyl-N-(9-trimethylsilylpurin-6-yl)benzamide 1,1-dimethylethyl (S)-2-(((4-methylphenyl)sulfonyl)-amino)-5-(((phenylmethoxy)carbonyl)amino)pentanoate 1,1-dimethylethyl [methyl-6-hydroximino-5,6,7,8,9-pentadeoxy-9(S)-[[(4-methylphenyl)sulfonyl]amino]-2,3-O-(1-methylethylidene)-β-D-ribo-dec-5-enofuranosid]uronates 9-(methyl 6(S),9(S)-(((tert-butyloxy)carbonyl)amino)-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-decafuranosyluronate)adenine 1,1-dimethylethyl [methyl-6-nitro-5,6,7,8,9,-pentadeoxy-9(S)-[[(4-methylphenyl)sulfonyl]amino]-2,3-O-(1-methyl-ethylidene)-β-D-ribo-dec-5-enofuranosid]uronates (2S,5S)-5-Amino-6-[(3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-tert-butoxycarbonylamino-hexanoic acid methyl ester (2S,6R)-tert-butyl 6-hydroxy-6-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-(4-methylphenylsulfonamido)-5-nitrohexanoate 1,1-dimethylethyl (methyl-5,7,8,9-tetradeoxy-6-O-((4-methylphenyl)sulfonyl)-9(S)-(((4-methylphenyl)sulfonyl)amino)-2,3-O-(1-methylethylidene)-β-D-allo-decofuranosid)uronate 1,1-dimethylethyl (S)-5-nitro-2-(((4-methylphenyl)sulfonyl)amino)pentanoate 1,1-dimethylethyl (S)-5-amino-2-(((4-methylphenyl)sulfonyl)-amino)pentanoate 1,1-dimethylethyl (methyl-5,7,8,9-tetradeoxy-9(S)-(((4-methylphenyl)sulfonyl)amino)-2,3-O-(1-methylethylidene)-β-D-ribo-6-deculofuranosid)uronate 1,1-dimethylethyl (methyl-6(S)-azido-5,6,7,8,9-pentadeoxy-9(S)-(((4-methylphenyl)sulfonyl)amino)-2,3-O-(1-methylethylidene)-β-D-ribo-decofuranosid)uronate (2R,3R,4R,5R)-2-((2S,5S)-5-acetamido-2-(benzyl((benzyloxy)carbonyl)amino)-6-ethoxy-6-oxohexyl)-5-(6-benzamido-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate (2S,5S)-2-amino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-(benzyl((benzyloxy)carbonyl)amino)hexanoic acid 2',3'-O-isopropylidenesinefungin 1-(6-benzoylamino-purin-9-yl)-6-diethoxyphosphoryl-O2,O3-isopropylidene-1,5,6-trideoxy-heptofuranurononitrile 1,1-dimethylethyl 1-(6-amino-9H-purin-9yl)-6(S)-azido-2,3-di-O-acetyl-1,5,6,7,8,9-hexadeoxy-9(S)-(((4-methylphenyl)sulfonyl)amino)-β-D-ribo-decofuranuronate (2S,5S)-tert-butyl 5-amino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-(4-methylphenylsulfonamido)hexanoate (2S,5S)-5-amino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-(4-methylphenylsulfonamido)hexanoic acid compound with 2,2,2-trifluoroacetic acid (1:1) 9-(methyl 9(S)-(((tert-butyloxy)carbonyl)amino)-6-cyano-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-decafuranosyluronate)adenine 9-(methyl 9(S)-(((tert-butyloxy)carbonyl)amino)-6-carboxamido-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-decafuranosyluronate)adenine N6-苯甲酰基腺嘌呤 9-(methyl 9(S)-(((tert-butyloxy)carbonyl)amino)-6-cyano-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-deca-6-enofuranosyluronate)-adenine (3aR,4S,6R,6aR)-tetrahydro-6-methoxy-2,2-dimethylfuro-[3,4-d][1,3]dioxole-4-carbaldehyde (2S,5S)-benzyl 6-((3aR,4R,6R,6aR)-6-(6-benzamido-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-2-(((benzyloxy)carbonyl)amino)-5-((tert-butoxycarbonyl)amino)hexanoate