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乌苯美司

乌苯美司

CAS号：58970-76-6
英文名：Ubenimex
分子式
C16H24N2O4
熔点
245°C (dec.)(lit.)
密度
1.197 g/cm3
分子量
308.373
沸点
604.7ºC at 760 mmHg
溶解度
信号词
危险品标志
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化合物简介
Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.
基本信息
中文名称
乌苯美司
英文名称
Ubenimex
中文别名
[S-(R*,S*)]-N-(3-氨基-2-羟基-1-氧代-4-苯丁基)-L-亮氨酸、贝他定、N-[(2S,3R)-3-氨基-2-羟基-4-苯丁酰]-L-亮氨酸、N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸、([2S,3R]-3-氨基-2-羟基-4-苯基丁酰基)-L-亮氨酸
英文别名
nk421、BENIMEX、BESTATIN、Bestatin,UbeniMex
CAS号
58970-76-6
分子式
C16H24N2O4
分子量
308.373
精确质量
308.174
PSA
112.65
LOGP
1.624
编号系统
UNII
I0J33N5627
物化性质
外观与性状
白色结晶粉末
密度
1.197 g/cm3
沸点
604.7ºC at 760 mmHg
熔点
245°C (dec.)(lit.)
闪点
319.5ºC
折射率
1.557
稳定性
Stable at normal temperatures and pressures.
储存条件
通风低温干燥,与库房食品原料分开存放
安全信息
RTECS号
OH2915000
安全说明
S22-S24/25
WGK Germany
3
生产方法及用途
用途
急、慢性细胞性白血病等病的辅助治疗
合成路线
N-[(2S,3S)-3-azido-2-hydroxy-4-phenylbutanoyl]-L-leucine benzyl ester
121445-53-2
N-[(2S,3S)-3-azido-2-hydroxy-4-phenylbutanoyl]-L-leucine benzyl ester
乌苯美司
58970-76-6
乌苯美司
上游原料
共找到54个上游原料 >
2-(3-tert-butoxycarbonylamino-2-oxo-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester
246506-78-5
2-(3-tert-butoxycarbonylamino-2-oxo-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester
(3S,5R,6S,9R)-3-[(1S)-1-hydroxy-2-phenylethyl]-9-methyl-6-(1-methyl-1-phenylethyl)-1,4-dioxaspiro[4.5]decan-2-one
121445-49-6
(3S,5R,6S,9R)-3-[(1S)-1-hydroxy-2-phenylethyl]-9-methyl-6-(1-methyl-1-phenylethyl)-1,4-dioxaspiro[4.5]decan-2-one
ethyl (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoate
180922-42-3
ethyl (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoate
(2S,3R)-2-acetoxy-3-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid
869115-78-6
(2S,3R)-2-acetoxy-3-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid
(2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoic acid
180922-44-5
(2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoic acid
(S)-benzyl 2-((4S,5S)-5-benzyl-2,2-dimethyl-1,3-dioxolane-4-carboxamido)-4-methylpentanoate
172025-46-6
(S)-benzyl 2-((4S,5S)-5-benzyl-2,2-dimethyl-1,3-dioxolane-4-carboxamido)-4-methylpentanoate
上游原料
2-(3-tert-butoxycarbonylamino-2-oxo-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester (3S,5R,6S,9R)-3-[(1S)-1-hydroxy-2-phenylethyl]-9-methyl-6-(1-methyl-1-phenylethyl)-1,4-dioxaspiro[4.5]decan-2-one ethyl (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoate (2S,3R)-2-acetoxy-3-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid (2S,3R)-2-hydroxy-4-phenyl-3-(tosylamino)butanoic acid (S)-benzyl 2-((4S,5S)-5-benzyl-2,2-dimethyl-1,3-dioxolane-4-carboxamido)-4-methylpentanoate N-苄氧羰基-D-苯丙氨酸 (4R,5S)-3,4-Dibenzyl-5-iodomethyl-oxazolidin-2-one (S-(R*,S*))-N-(3-amino-2-hydroxy-4-phenylbutyroyl)-L-leucine Z-D-phenylalanine ethyl ester (4R,5S)-5-benzyl-4-(hydroxymethyl)-1,3-oxazolidin-2-one benzyl ((4R,5S)-4-benzyl-2-phenyl-4,5-dihydrooxazole-5-carbonyl)-L-leucinate N-Cbz-D-苯丙氨醛 苯乙醛 溴化苯基镁 N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester methyl N-{(2S,3R)-2-O-benzyl-4-phenyl-3-[9-phenyl-9-fluorenyl-amino]-butanoyl}-L-leucine N-[(2S,3S)-3-azido-2-hydroxy-4-phenylbutanoyl]-L-leucine benzyl ester (2S,3R)-2-O-benzyl-4-phenyl-3-[(9-phenyl-9-fluorenyl)-amino]-phenylbutanoic acid Cbz-D-苯丙氨醇 ethyl (2S,3R)-3-azido-2-hydroxy-4-phenylbutanoate [1-benzyl-3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid tert-butyl ester benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate (2S,3R)-methyl-2,3-epoxy-4-phenylbutanoic acid (2S)-2-氨基-4-甲基戊酸甲酯 (2S,3R)-3-氨基-2-羟基-4-苯丁酸 乌苯美司侧链 N-Boc bestatin benzyl (S)-2-isocyano-4-methylpentanoate (3R,4R)-5-phenyl-4-((9-phenyl-9H-fluoren-9-yl)amino)pent-1-yn-3-ol (2S,3R)-2-acetoxy-3-amino-4-phenylbutanoic acid L-亮氨酸苄基酯 N-((2R,3R)-3-(benzyloxy)-1-phenylpent-4-yn-2-yl)-9-phenyl-9H-fluoren-9-amine ((2S,3R)-2-acetoxy-3-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucine N-<(benzyloxy)carbonyl>-(2R)-amino-1-phenylbut-3-ene (1R)-1-((4R,5S)-5-(hydroxy(phenyl)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol methyl (4R,5S)-2-oxo-4-phenylmethyl-1,3-oxazolidine-5-carboxylate methyl (2S,3R)-3-azido-2-hydroxy-4-phenylbutanoate 2-(3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester Benzyl-((R)-1-benzyl-allyl)-carbamic acid benzyl ester (2R,3S)-methyl 3-bromo-2-hydroxy-4-phenylbutanoate (4R,5S)-3,4-dibenzyl-5-(hydroxymethyl)oxazolidin-2-one (R)-benzyl (1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate (2S,3R)-3-(Boc-氨基)-2-羟基-4-苯基丁酸 benzyl ((3R)-3-(((benzyloxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-L-leucinate (3aS,6S,6aS)-2,2-dimethyl-6-phenyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one (3S,5R,6S,9R)-3-[(1R)-1-azido-2-phenylethyl]-9-methyl-6-(1-methyl-1-phenylethyl)-1,4-dioxaspiro[4.5]decan-2-one (2S,3R)-3-azido-2-hydroxy-4-phenylbutanoic acid
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