百科

D-(-)-泛酰内酯

CAS号：599-04-2

英文名：(R)-pantolactone

分子式

C6H10O3

熔点

91°C(lit.)

密度

1.165g/cm3

分子量

130.142

沸点

120-122°C15mm Hg(lit.)

溶解度

信号词

危险品标志

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化合物简介

An important intermediate in the synthesis of pantothenic acid as well as a degradation product of pantothneic acid in the liver. Causes disorientation and hypothermia, and prevents phenamine-induced hyperthermia.

基本信息

中文名称

D-(-)-泛酰内酯

英文名称

(R)-pantolactone

中文别名

Alpha-羟基-β,β-二甲基-γ-丁内酯、二氢-3-羟基-4,4-二甲基-2(3H)呋喃酮、D-(-)-2-羟基-3,3-二甲基

英文别名

D-(-)-PANTOLACTONE、(3R)-3-hydroxy-4,4-dimethyloxolan-2-one、2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-

CAS号

599-04-2

分子式

C6H10O3

分子量

130.142

精确质量

130.063

PSA

46.53

LOGP

-0.0697

编号系统

MDL号

MFCD00005392

物化性质

外观与性状

白色结晶粉末或晶体

密度

1.165g/cm3

沸点

120-122°C15mm Hg(lit.)

熔点

91°C(lit.)

闪点

120-122°C/15mm

折射率

-50.8 ° (C=2, H2O)

储存条件

2-8ºC

安全信息

安全说明

S22-S24/25

WGK Germany

海关编码

2932209090

生产方法及用途

用途

一、用途：混旋泛酸钙的中间体。

合成路线

上游原料

(R)-4,4-dimethyl-3-(((4aR,6R,8aS)-4,4a,6,8a-tetrahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)dihydrofuran-2(3H)-one

223710-78-9

S-(3-oxo-3-(propylamino)propyl) (2R)-4-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanethioate

158045-11-5

(E)-5-(tert-butyldimethylsilyloxy)-4,4-dimethylpent-2-en-1-ol

28227-36-3

(R)-2-acetoxy-3,3-dimethyl-γ-butyrolactone

133094-78-7

3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

158045-17-1

(R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,3-dimethylbutanal

下游产品

N-(3-amino-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide

(S)-3-Azido-4,4-dimethyldihydrofuran-2(3H)-one

79-50-5

DL-泛酰内酯

上游原料

(R)-4,4-dimethyl-3-(((4aR,6R,8aS)-4,4a,6,8a-tetrahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)dihydrofuran-2(3H)-one S-(3-oxo-3-(propylamino)propyl) (2R)-4-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanethioate (E)-5-(tert-butyldimethylsilyloxy)-4,4-dimethylpent-2-en-1-ol (R)-2-acetoxy-3,3-dimethyl-γ-butyrolactone 3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one (R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,3-dimethylbutanal (R)-3-(benzyloxy)-2,2-dimethyl-4-oxobutyl acetate 乙醛酸乙酯异丁醛 3-(2-bromo-1-ethoxyethoxy)-2-methylprop-1-ene (R,S)-3-hydroxy-4-[[3-(propylamino)-3-oxopropyl]thio]-2,2-dimethyl-4-oxobutan-1-ol, 1-methyl phosphate ester 丙酮酸乙酯乙酰氯醋酸乙烯酯泛醇杂质B 奎宁 Γ-二甲基丁内酯 1-amino-1-deoxy-D-galactitol (3R,4R)-3-(benzyloxy)-4,5-dihydroxy-2,2-dimethylpentyl acetate (E)-3-[((R)-2,2,5,5-Tetramethyl-[1,3]dioxane-4-carbonyl)-amino]-acrylic acid allyl ester (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropan-1-ol (R)-3-(((4R,6R)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-6-yl)oxy)-4,4-dimethyldihydrofuran-2(3H)-one (R)-2,4-dihydroxy-N-[(1R)-2-endo-hydroxy-3-endo-bornyl]-3,3-dimethylbutyramide (R)-3,3-dimethyl-2,4-bis((2,2,4,4-tetramethyloxazolidine-3-carbonyl)oxy)butanoic acid DL-泛酰内酯苯甲酰甲酸甲酯 (E)-5-(tert-butyldimethylsilyloxy)-4,4-dimethylpent-2-enoic acid ethyl ester (S)-2,2,3,3,6,6,9,9,10,10-decamethyl-5-vinyl-4,8-dioxa-3,9-disilaundecane (2R)-4-acetoxy-2-(benzyloxy)-3,3-dimethylbutanoic acid 2,2-二甲基-3-羟基丙醛 ((2R,3R)-3-(1-((tert-butyldimethylsilyl)oxy)-2-methylpropan-2-yl)oxiran-2-yl)methanol (RS)-2-acetoxy-3,3-dimethyl-γ-butyrolactone (R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-3,3-dimethyl-butyric acid tert-Butyl-[2-((2R,3S)-3-chloromethyl-oxiranyl)-2-methyl-propoxy]-dimethyl-silane tert-butyl((4,4-dimethyl-4,5-dihydrofuran-2-yl)oxy)dimethylsilane 二氢-4,4-二甲基-2,3-呋喃二酮 (R,S)-3-hydroxy-4-((3-(propylamino)-3-oxopropyl)thio)-2,2-dimethyl-4-oxobutan-1-ol, phosphate ester R(-)pantoyllactone-β-D-glucopyranoside (R,S)-4,4,4-tris(methylthio)-2,2-dimethyl-1,3-butanediol, 1-dimethyl phosphate (3S,4E,6Z)-3-hydroxy-2,2-dimethyl-4,6-octadienal 1,1-二甲氧基丙酮 4,4-dimethyltetrahydrofuran-2-ol ethyl trans-4,4-dimethyl-5-hydroxypent-2-enoate 甲醇马钱子碱 (R)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropyl acetate

下游产品

Γ-二甲基丁内酯 N-(3-amino-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide 右旋泛醇 D-泛酸 (S)-3-Azido-4,4-dimethyldihydrofuran-2(3H)-one DL-泛酰内酯 (2R)-2,4-dihydroxy-N-[3-(2-hydroxyethylamino)-3-oxopropyl]-3,3-dimethylbutanamide 2-[(2,4-二羟基-3,3-二甲基丁酰基)氨基]乙烷磺酸 4-[[(2R)-2,4-二羟基-3,3-二甲基-1-氧代丁基]氨基]-丁酸 (R)-α-丙烯酰基氧基-β,β-二甲基-γ-丁内酯 N-[2-[(5-bromopyridin-2-yl)sulfamoyl]ethyl]-2,4-dihydroxy-3,3-dimethylbutanamide