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Alpha-葡萄糖苷酶

Alpha-葡萄糖苷酶

CAS号：59920-31-9

英文名：2,5-DIDEOXY-2,5-IMINO-D-MANNITOL

分子式

C6H13NO4

熔点

101-103ºC

密度

1.408g/cm3

分子量

163.172

沸点

395.9ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Many pyrrolidines are powerful inhibitors of glycohydrolases, enzymes responsible for cleavage of glycosidic bonds, glycoprotein processing and the gastrointestinal breakdown of dietary carbohydrates. These compounds are charged at physiological pH and are believed to associate with acidic amino acids at the active site. Inhibition of glycohydrolases could be of therapeutic value for the treatment of viral infections, cancer, diabetes, and obesity.

基本信息

中文名称

Alpha-葡萄糖苷酶

英文名称

2,5-DIDEOXY-2,5-IMINO-D-MANNITOL

中文别名

2,5-二脱氧-2,5-亚氨基-d-甘露醇

英文别名

2,4-DICHLORO-5,6-DIMETHYL-NICOTINIC ACID ETHYL ESTER 1-OXIDE,WHITE SOLID、Phenol,2,5-dicyclohexyl

CAS号

59920-31-9

分子式

C6H13NO4

分子量

163.172

精确质量

163.084

PSA

92.95

LOGP

-2.638

编号系统

EINECS号

232-889-8

物化性质

外观与性状

灰白色固体

密度

1.408g/cm3

沸点

395.9ºC at 760 mmHg

熔点

101-103ºC

闪点

221.9ºC

折射率

1.559

储存条件

2-8ºC

安全信息

安全说明

S26; S36

危险类别码

R36/37/38

危险品标志

Xi

合成路线

5-叠氮基-5-脱氧-D-果糖

5-叠氮基-5-脱氧-D-果糖

Alpha-葡萄糖苷酶

Alpha-葡萄糖苷酶

上游原料

共找到52个上游原料 >

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

(2R,3R,4R,5R)-2-(hydroxy-methyl)-3,4-di-O-benzyl-5-(O-benzyl-methyl)-pyrrolidine

(2R,3R,4R,5R)-2-(hydroxy-methyl)-3,4-di-O-benzyl-5-(O-benzyl-methyl)-pyrrolidine

(2S,3S,4S,5S)-1,3,4-tris(benzyloxy)hept-6-ene-2,5-diyl dimethanesulfonate

(2S,3S,4S,5S)-1,3,4-tris(benzyloxy)hept-6-ene-2,5-diyl dimethanesulfonate

N-benzyloxycarbonyl-3-O-benzyyl-2,5-dideoxy-2,5-imino-D-mannitol

N-benzyloxycarbonyl-3-O-benzyyl-2,5-dideoxy-2,5-imino-D-mannitol

5-azideo-3,4-di-O-benzoyl-5-deoxy-1,2-O-isopropylidene-β-L-sorbopyranose

5-azideo-3,4-di-O-benzoyl-5-deoxy-1,2-O-isopropylidene-β-L-sorbopyranose

5-叠氮基-5-脱氧-3,4-双-o-乙酰基-1,2-o-异亚丙基-beta-D-果糖

5-叠氮基-5-脱氧-3,4-双-o-乙酰基-1,2-o-异亚丙基-beta-D-果糖

上游原料

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol (2R,3R,4R,5R)-2-(hydroxy-methyl)-3,4-di-O-benzyl-5-(O-benzyl-methyl)-pyrrolidine (2S,3S,4S,5S)-1,3,4-tris(benzyloxy)hept-6-ene-2,5-diyl dimethanesulfonate N-benzyloxycarbonyl-3-O-benzyyl-2,5-dideoxy-2,5-imino-D-mannitol 5-azideo-3,4-di-O-benzoyl-5-deoxy-1,2-O-isopropylidene-β-L-sorbopyranose 5-叠氮基-5-脱氧-3,4-双-o-乙酰基-1,2-o-异亚丙基-beta-D-果糖 3-O-(2-bromomethyl)benzyl-1,2:4,5-di-O-isopropylidene-β-D-fructopyranose 5-叠氮基-5-脱氧-D-果糖 (2R,3R,4R,5R)-1-benzyl-2,5-bis(hydroxymethyl)-3,4-dihydroxypyrrolidine N-benzyl-3,4-di-O-benzyl-2,5-dideoxy-2,5-imino-D-mannitol (5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-pyrroline methyl 3-O-benzyl-2-O-trifluoromethanesulphonyl-α-D-glucofuranoside-5,6-carbonate (2S,5S)-N-(methoxycarbonyl)-5-(hydroxymethyl)-2-(p-methoxyphenyl)-3-pyrroline (R)-1-((4S,5R)-5-((R)-1-(((benzyloxy)carbonyl)amino)-2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl methanesulfonate (2R,3R,4R,5R)-4-(benzyloxy)-2-((benzyloxy)methyl)-5-(hydroxymethyl)pyrrolidin-3-ol (2S,3R,4R,5R)-3,4-Diacetoxy-5-acetoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-methyl ester methyl 2-azido-6-O-benzoyl-3-O-benzyl-2-deoxy-α-D-mannofuranoside L-(+)-阿拉伯糖 (3As,5s,6r,6as)-5-(羟基甲基)-2,2-二甲基四氢呋喃并[2,3-d][1,3]二氧代l-6-醇 N-Benzhydryl-2,5-anhydro-2,5-imino-D-mannitol 5-azido-5-deoxy-1,2-O-isopropylidene-3,4-O-(o-xylylene)-β-D-fructopyranose (+)-3,5-di-O-benzyl-1,2,-O-isopropylidene-α-L-xylofuranose (-)-3-deoxy-1,2:4,5-di-O-isopropylidene-β-D-fructofuranos-3-yl benzoate (2R,3R,4R,5R)-N-benzyloxycarbonyl-2-benzyloxymethyl-3,4-dihydroxy-5-hydroxymethylpyrrolidine 3-O-benzoyl-1,2-O-isopropylidene-β-D-fructopyranose 二丙酮-D-葡萄糖 (2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-<(benzyloxy)methyl>pyrrolidino<1,2-c>oxazole-3-one (2R,3R,4R,5R)-N-tert-butoxycarbonyl-3,4-bis(methoxymethyloxy)-5-hydroxymethyl-2-trityloxymethylpyrrolidine 3-O-(2-bromomethyl)benzyl-1,2-O-isopropylidene-β-D-fructopyranose 3,4-di-O-benzoyl-5-deoxy-5-iodo-1,2-O-isopropylidene-β-L-sorbopyranose (2R,3R,4R,5R)-3,4-Dihydroxy-2-hydroxymethyl-5-(4-methoxy-phenyl)-pyrrolidine-1-carboxylic acid methyl ester N-benzyl-3,4,6-tri-O-benzyl-2,5-dideoxy-2,5-imino-D-mannitol 5-叠氮基-5-脱氧-1,2-o-异亚丙基-beta-D-果糖 N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-2,6-di-O-methanesulfonyl-D-glucitol (2S,3S,4S,5S)-1,3,4-tris(benzyloxy)-6,7-dihydroxyheptane-2,5-diyl dimethanesulfonate dimethyl (2S,3R,4R,5R)-3,4-diacetoxy-5-(acetoxymethyl)pyrrolidine-1,2-dicarboxylate 3,4-双邻乙酰基-1,2-邻异亚丙基-5-邻磺酰基-alpha-l-吡喃 (3R,4R)-1,3,4-Tris-benzyloxy-hex-5-en-2-one oxime 5-酮果糖 1,2-O-isopropylidene-3,4-di-O-benzoyl-β-D-fructopyranose methyl 2-azido-6-O-benzoyl-3-O-benzyl-2-deoxy-5-O-methanesulphonyl-α-D-mannofuranoside (3R,4R,5R)-5-hydroxy-3,4,6-tribenzyloxy-1-hexene 3-O-苄基-1,2:5,6-O-双异丙叉-α-D-呋喃葡萄糖 2,3,5-三-O-(苯基甲基)-D-呋喃阿拉伯糖 1,2:4,5-二-O-异亚丙基-BETA-D-吡喃果糖 (2R,3R,4R,5R)-2-(acetoxymethyl)-1-(methoxycarbonyl)-5-(4-methoxyphenyl)pyrrolidine-3,4-diyl diacetate (2S,3R,4R,5S)-2,5-dihydroxy-1,3,4-tris(benzyloxy)-6-heptene