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25-二羟基维生素D2

25-二羟基维生素D2

CAS号：60133-18-8

英文名：1α,25-dihydroxyvitamin D2

分子式

C28H44O3

熔点

密度

1.066 g/cm3

分子量

428.647

沸点

577.655ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

The active metabolite of Vitamin D2.

基本信息

中文名称

25-二羟基维生素D2

英文名称

1α,25-dihydroxyvitamin D2

中文别名

1α,25-Dihydroxycalciferol、1α,25-二羟基维生素D2、1ALPHA,25-二羟基维生素 D2

英文别名

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol、1alpha,25-dihydroxyvitamin D2、1α,25-Dihydroxy Vitamin D2

CAS号

60133-18-8

分子式

C28H44O3

分子量

428.647

精确质量

428.329

PSA

60.69

LOGP

5.7267

编号系统

UNII

5RWP08OQ36

物化性质

密度

1.066 g/cm3

沸点

577.655ºC at 760 mmHg

闪点

242.511ºC

折射率

1.554

储存条件

-20ºC

安全信息

安全说明

36/37-45

WGK Germany

3

危险类别码

R23/24/25; R63

危险品运输编码

UN 2811

危险品标志

T

危险性防范说明

P260; P280; P284; P301 + P310; P310

危险标志

GHS06, GHS08

危险性描述

H301 + H311; H330; H372

信号词

Danger

合成路线

1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D2 tert-butyldimethylsilyl ether

1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D2 tert-butyldimethylsilyl ether

25-二羟基维生素D2

25-二羟基维生素D2

上游原料

共找到42个上游原料 >

[2S-(1E,2α,3β,5α)]-[3,5-bis[[(1,1dimethylethyl)dimethylsilyl]oxy]-2-hydroxy-2-methylcyclohexylidene]acetic acid ethyl ester

[2S-(1E,2α,3β,5α)]-[3,5-bis[[(1,1dimethylethyl)dimethylsilyl]oxy]-2-hydroxy-2-methylcyclohexylidene]acetic acid ethyl ester

[2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester

[2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester

(4S,7aR)-7a-甲基-1-[(2S)-1-氧代-2-丙基]八氢-1H-茚-4-基苯甲酸酯

(4S,7aR)-7a-甲基-1-[(2S)-1-氧代-2-丙基]八氢-1H-茚-4-基苯甲酸酯

diethyl ((2S,3S,E)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)-6-(methoxymethoxy)-6-methylhept-4-en-3-yl) phosphate

diethyl ((2S,3S,E)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)-6-(methoxymethoxy)-6-methylhept-4-en-3-yl) phosphate

25-羟基维生素 D2

25-羟基维生素 D2

(20S)-des-A,B-8β-(benzoyloxy)-20-<(2'R,6'R)-6'-methyl-4'-oxo-1',3'-dioxan-2'-yl>pregnane

(20S)-des-A,B-8β-(benzoyloxy)-20-<(2'R,6'R)-6'-methyl-4'-oxo-1',3'-dioxan-2'-yl>pregnane

上游原料

[2S-(1E,2α,3β,5α)]-[3,5-bis[[(1,1dimethylethyl)dimethylsilyl]oxy]-2-hydroxy-2-methylcyclohexylidene]acetic acid ethyl ester [2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester (4S,7aR)-7a-甲基-1-[(2S)-1-氧代-2-丙基]八氢-1H-茚-4-基苯甲酸酯 diethyl ((2S,3S,E)-2-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyloctahydro-1H-inden-1-yl)-6-(methoxymethoxy)-6-methylhept-4-en-3-yl) phosphate 25-羟基维生素 D2 (20S)-des-A,B-8β-(benzoyloxy)-20-<(2'R,6'R)-6'-methyl-4'-oxo-1',3'-dioxan-2'-yl>pregnane 22-Oxo-5α,8α-(4-phenyl-3,5-dioxo-1,2,4-triazolidine-1,2-diyl)-23,24-dinor-6-cholene-1α,3β-diyl diacetate 四氢-2-[(2R)-1,1,2-三甲基-3-(苯磺酰基)丙氧基]-2H-吡喃 (1R,4S,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7a-甲基八氢-1H-茚-4-基苯甲酸酯 [3S-(1Z,3a,5b)]-[2-[3,5-二[(叔丁基)二甲基硅氧基]-2-亚甲基环己亚基]乙基]二苯基氧化膦 (2S,3S,E)-2-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)-6-(methoxymethoxy)-6-methylhept-4-en-3-ol (R)-2,3-dimethyl-4-phenylthio-2-butanol (S)-3-hydroxy-2,3-dimethylbutyl 4-methylbenzenesulfonate [1R-(1α,2E,4α,6α)]-[1-methyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]hept-2-ylidene]acetic acid ethyl ester (2S-(1E,2α,3β,5α))-(2,3,5-tris(acetyloxy)-2-methylcyclohexylidene)acetic acid ethyl ester [3S-(1Z,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]-1-chloroethane <3S-<3β,4α,3-<(2R*),1R*(1α,3aβ,4α,7aβ)>>>-3-<2-(octahydro-4-hydroxy-7a-methyl-1H-inden-1-yl)propyl>-2,5,5-trimethyl-4-isoxazolidinecarboxylic acid methyl ester (1R,3aR,7aR)-八氢-1-[(1R,2E,4S)-5-(甲氧基甲氧基)-1,4,5-三甲基-2-己烯-1-基]-7a-甲基-4H-茚-4-酮 (22R)-des-A,B-8β-(benzoyloxy)-22(((1'R)-2'-carboxy-1'-methylethyl)oxy)-23-cholestyn-25-ol (3S-(3β,4α,3-((2R*),1R*(1α,3aβ,4α,7aα))))-3-(2-(octahydro-4-hydroxy-7a-methyl-1H-inden-1-yl)propyl)-2,5,5-trimethyl-4-isoxazolidinemethanol (1R-(1α(R*),3aβ,4α,7aα,(3S*,4S*)))-octahydro-7a-methyl-1-(1-methyl-2-(4-((((4-methylphenyl)sulfonyl)oxy)methyl)-2,5,5-trimethyl-3-isoxazolidinyl)ethyl)inden-4-ol 1R-(1α(1R*,2E,4S*),3aβ,7aα)-octahydro-1-(5-((trimethylsilyl)oxy)-1,4,5-trimethyl-2-hexenyl)-7a-methyl-4H-inden-4-one (22R)-des-A,B-8β-(benzoyloxy)-25-<(methoxymethyl)oxy>-22-<<(1'R)-3'-oxo-3'-<(methoxymethyl)oxy>-1'-methylpropyl>-oxy>cholest-23-yne <1R-<1α(R*),3aβ,4α,7aα,(3S*,4S*)>>-octahydro-7a-methyl-1-<1-methyl-2-(2,4,5,5-tetramethyl-3-isoxazolidinyl)ethyl>-1H-inden-4-ol (22R)-des-A,B-8β-(benzoyloxy)-25-[(methoxymethyl)oxy]cholest-23-yn-22-ol Phosphoric acid diethyl ester (E)-(S)-4-methoxymethoxy-4-methyl-1-[(S)-1-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-ethyl]-pent-2-enyl ester (22E,24S)-des-A,B-25-<(methoxymethyl)oxy>-8,22-ergostadien-8-yl Trifluoromethanesulfonate <1R-<1α(R*,S*,S*),3aβ,4α,7aα>>-octahydro-γ-(dimethylamino)-4-hydroxy-α,α,β,ε,7a-pentamethyl-1H-indene-1-pentanol (2S)-2,3-二甲基-1,3-丁二醇 [1R-[1β(R*,Z),3aα,4β,7aβ]]-octahydro-7a-methyl-1-[1-methyl-3-(methylimino)propyl]-1H-inden-4-ol N-oxide (1R,4S,7aR)-1-[(2R,3E,5R)-5,6-二甲基-3-庚烯-2-基]-7A-甲基八氢-1H-茚-4-醇 1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D2 tert-butyldimethylsilyl ether Phosphoric acid (E)-(S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-4-methoxymethoxy-4-methyl-pent-2-enyl ester diethyl ester [2S-(1E,2α,3β,5α)]-[2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene]acetic acid ethyl ester (R)-2,3-二甲基-4-(苯基磺酰基)-2-丁醇 previtamin D [2S-(1E,2α,3β,5α)]-[5-acetyl-2,3-bis(acetyloxy)-2-methyl-cyclohexylidene]acetic acid ethyl ester (1S,3R,9S,10R,13R,14R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1,3-diyl diacetate (22E)-5,7,22-ergostatriene-1α,3β,25-triol 3,3-二甲基丙烯酸甲酯 (S)-2-[(1R,3aR,4S,7aR)-octahydro-4-[(1,1-dimethylethyl)dimethylsilyloxy]-7a-methyl-1H-inden-1-yl]propanal