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顺式-4-羟基-L-脯氨酸

顺式-4-羟基-L-脯氨酸

CAS号：618-27-9

英文名：cis-4-hydroxy-L-proline

分子式

C5H9NO3

熔点

257ºC

密度

1.395 g/cm3

分子量

131.13

沸点

355.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.

基本信息

中文名称

顺式-4-羟基-L-脯氨酸

英文名称

cis-4-hydroxy-L-proline

中文别名

顺-4-羟基-L-脯氨酸、羟脯氨酸

英文别名

L-Proline, 4-hydroxy-, cis-、(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid、cis-4-Hydroxy-L-proline

CAS号

618-27-9

分子式

C5H9NO3

分子量

131.13

精确质量

131.058

PSA

69.56

LOGP

-0.8774

编号系统

MDL号

MFCD00064319

物化性质

外观与性状

白色固体

密度

1.395 g/cm3

沸点

355.2ºC at 760 mmHg

熔点

257ºC

闪点

168.6ºC

稳定性

Stable under normal temperatures and pressures.

储存条件

Store at RT.

安全信息

安全说明

S24/25

危险类别码

R36/37/38

WGK Germany

3

海关编码

2933990090

危险品标志

Xi

生产方法及用途

生产方法

将明胶、骨胶、干酪素、大豆表皮蛋白质等用盐酸水解,再用亚硝化法提取亚氨酸后经树脂层析后精制、结晶而成。

用途

可用作增味剂、营养强化剂或香味料。主要用于果汁、清凉饮料和营养饮料中。

合成路线

共找到8条合成路线 >

(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸

(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸

顺式-4-羟基-L-脯氨酸

顺式-4-羟基-L-脯氨酸

上游原料

共找到34个上游原料 >

(S)-2-(((S)-1-phenylethyl)amino)pent-4-enamide

(S)-2-(((S)-1-phenylethyl)amino)pent-4-enamide

(2S,4S)-1-(3,3-dimethylbutoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate

(2S,4S)-1-(3,3-dimethylbutoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate

cis-1-ethoxycarbonyl-4-hydroxy-DL-prolin-ethyl ester

cis-1-ethoxycarbonyl-4-hydroxy-DL-prolin-ethyl ester

L-羟基脯氨酸

L-羟基脯氨酸

N-acetyl-trans-4-(tosyloxy)-L-proline

N-acetyl-trans-4-(tosyloxy)-L-proline

(1S,4S)-N-Cbz-6-(R/S)-hydroxy-5-oxa-2-aza-bicyclo[2.2.1]heptane

(1S,4S)-N-Cbz-6-(R/S)-hydroxy-5-oxa-2-aza-bicyclo[2.2.1]heptane

下游产品

共找到8个下游商品 >

(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸

(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸

(4S)-4-羟基-L-脯氨酸甲酯

(4S)-4-羟基-L-脯氨酸甲酯

(2s,4s)-N-cbz-2-羟甲基-4-氧-吡咯烷

(2s,4s)-N-cbz-2-羟甲基-4-氧-吡咯烷

N-Boc-顺式-4-羟基-L-脯氨酸

N-Boc-顺式-4-羟基-L-脯氨酸

(2S)-1-(2,4-dinitrophenyl)-4-hydroxypyrrolidine-2-carboxylic acid

(2S)-1-(2,4-dinitrophenyl)-4-hydroxypyrrolidine-2-carboxylic acid

(4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-L-proline

(4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-L-proline

上游原料

(S)-2-(((S)-1-phenylethyl)amino)pent-4-enamide (2S,4S)-1-(3,3-dimethylbutoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate cis-1-ethoxycarbonyl-4-hydroxy-DL-prolin-ethyl ester L-羟基脯氨酸 N-acetyl-trans-4-(tosyloxy)-L-proline (1S,4S)-N-Cbz-6-(R/S)-hydroxy-5-oxa-2-aza-bicyclo[2.2.1]heptane (2s,4s)-N-cbz-2-羟甲基-4-氧-吡咯烷 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2S,4S)-4-(benzoyloxy)pyrrolidine-2-carboxylate (2s,4r)-1,2-二苄氧羰基-4-羟基吡咯烷 N-Benzoyl-2(S)-(2-propenyl)glycin-(1R,2S,5R)-menthylester L-脯氨酸 (2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸 5-triphenylmethyl-2-oxa-5-aza-bicyclo(2.2.1)heptan-3-one (3R,5S)-5-(methoxycarbonyl)-1-acetylpyrrolidin-3-yl 4-methylbenzenesulfonate 反-N-苄氧羰基-4-羟基-L-脯氨酸 (2S,4S)-1,2-二苄氧羰基-4-羟基吡咯烷 (2S,4S)-N-benzyloxycarbonyl-4-formyloxyproline methyl ester (3S,5S)-5-(iodomethyl)-3-(((S)-1-phenylethyl)amino)dihydrofuran-2(3H)-one cis-1-ethoxycarbonyl-4-hydroxy-L-proline N-乙酰-L-4-羟基脯氨酸 (S)-2,2-Bis(trifluormethyl)-4-(3-diazo-2-oxopropyl)-1,3-oxazolidin-5-on N-cbz-4-氧-L-脯氨酸 (6S,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one (S)-3,3-bis(trifluoromethyl)dihydropyrrolo[1,2-c]oxazole-1,6(3H,5H)-dione (2S,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid N-CBZ-羟脯氨酸甲酯 benzyl (2S,4S)-2-formyl-4-hydroxypyrrolidine-1-carboxylate (4S)-4-羟基-L-脯氨酸甲酯 trans-N-trityl-4-hydroxy-L-proline methyl 1-acetyl-trans-4-hydroxy-L-proplinate N-Boc-顺式-4-羟基-L-脯氨酸 (1S,4S)-3-(R/S)-methoxy-2-oxa-5-aza-bicyclo[2.2.1]heptane (1S,4S)-N-Cbz-6-(R/S)-methoxy-5-oxa-2-aza-bicyclo[2.2.1]heptane

下游产品

(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸 (4S)-4-羟基-L-脯氨酸甲酯 (2s,4s)-N-cbz-2-羟甲基-4-氧-吡咯烷 N-Boc-顺式-4-羟基-L-脯氨酸 (2S)-1-(2,4-dinitrophenyl)-4-hydroxypyrrolidine-2-carboxylic acid (4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-hydroxy-L-proline H-顺式-4-氟-脯氨酸 L-erythro-4-氟谷氨酸