百科

苯丁抑制素盐酸盐

苯丁抑制素盐酸盐

CAS号：65391-42-6

英文名：Bestatin hydrochloride

分子式

C16H25ClN2O4

熔点

216-218°C

密度

分子量

344.834

沸点

604.7ºC at 760 mmHg

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.

基本信息

中文名称

苯丁抑制素盐酸盐

英文名称

Bestatin hydrochloride

中文别名

N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸盐酸盐、盐酸乌苯美司、盐酸贝他定、贝他定盐酸、盐酸倍他定、N-[(2S,3R)-3-氨基-2-羟基-4苯基丁]-L-亮氨酸盐酸盐

英文别名

BESTATIN HYDROCHLORIDE

CAS号

65391-42-6

分子式

C16H25ClN2O4

分子量

344.834

精确质量

344.15

PSA

112.65

LOGP

2.426

编号系统

EINECS号

613-790-2

物化性质

沸点

604.7ºC at 760 mmHg

熔点

216-218°C

闪点

319.5ºC

储存条件

-20ºC

安全信息

安全说明

S22; S24/25; S36; S26

危险类别码

R20/21/22

WGK Germany

3

海关编码

29242995

危险品标志

Xn

合成路线

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

苯丁抑制素盐酸盐

苯丁抑制素盐酸盐

上游原料

共找到23个上游原料 >

methyl (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoate

methyl (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoate

[1-benzyl-3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid tert-butyl ester

[1-benzyl-3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid tert-butyl ester

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate

ethyl (4R,5S)-4-benzyl-2-oxooxazolidine-5-carboxylate

ethyl (4R,5S)-4-benzyl-2-oxooxazolidine-5-carboxylate

(2S)-2-氨基-4-甲基戊酸甲酯

(2S)-2-氨基-4-甲基戊酸甲酯

methyl ((4R,5S)-4-benzyl-2-oxooxazolidine-5-carbonyl)-L-leucinate

methyl ((4R,5S)-4-benzyl-2-oxooxazolidine-5-carbonyl)-L-leucinate

上游原料

methyl (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoate [1-benzyl-3-cyano-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid tert-butyl ester benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-hydroxy-4-phenylbutanoyl]-L-leucinate ethyl (4R,5S)-4-benzyl-2-oxooxazolidine-5-carboxylate (2S)-2-氨基-4-甲基戊酸甲酯 methyl ((4R,5S)-4-benzyl-2-oxooxazolidine-5-carbonyl)-L-leucinate 乌苯美司侧链 methyl (2S,3R)-3-(benzyloxycarbonyl)amino-2-formyloxy-4-phenylbutanoate (4S,5R)-4-methoxycarbonylmethyl-5-phenyloxazolidin-2-one 2-(3-tert-butoxycarbonylamino-2-oxo-4-phenylbutyrylamino)-4-methylpentanoic acid benzyl ester methyl (4S,5R)-2-benzyloxy-5-phenyloxazoline-4-acetate (R)-methyl 2-((4S,5R)-2-(benzyloxy)-5-phenyl-4,5-dihydrooxazol-4-yl)-2-hydroxyacetate (4R,5S)-4-benzyl-2-oxo-5-oxazolidinecarboxylic acid [(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-2,3-isopropylidene-4-phenylbutanoyl]-L-leucine methyl ester benzyl N-[(2S,3R)-3-(N-benzyloxycarbonyl)amino-2-tert-butyldimethylsiloxy-4-phenyl-butanoyl]-L-leucinate (4R,5S)-4-benzyl-3-[(tert-butoxy)carbonyl]-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid Β-硝基苯乙烷 O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol O-[(2S)-hydroxy-(3R)-3-nitro-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-2,3-isopropylidene-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol (2R,3R)-3-(N-(benzyloxycarbonyl)amino)-2-hydroxy-4-phenylbutanoic acid methyl ester L-亮氨酸甲酯盐酸盐 Boc-D-苯丙氨酸