百科

毛喉素

毛喉素

CAS号：66428-89-5

英文名：forskolin

分子式

C22H34O7

熔点

277ºC

密度

分子量

410.501

沸点

溶解度

信号词

危险品标志

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化合物简介

Forskolin (coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac.

基本信息

中文名称

毛喉素

英文名称

forskolin

中文别名

英文别名

Flavopirodol、(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-Trihydroxy-3,4a,7,7,10a -pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl ace tate、(+/-)-Flavopiridol、Alvocidib、vopiridol(Alvocidib)、Alvocidib,Free Base

CAS号

66428-89-5

分子式

C22H34O7

分子量

410.501

精确质量

410.23

PSA

113.29

LOGP

1.5199

物化性质

熔点

277ºC

合成路线

乙酸酐

1alpha,6beta,7beta,9alpha-四羟基-8,13-环氧-赖百当-14-烯-11-酮

1alpha,6beta,7beta,9alpha-四羟基-8,13-环氧-赖百当-14-烯-11-酮

毛喉素

上游原料

共找到38个上游原料 >

(2aR,2a1R,3R,5aR,8aR)-3-methoxy-2a1,6,6-trimethyl-2a,2a1,3,5a,6,7,8,8a-octahydro-2H-naphtho[1,8-bc]furan-2-one

(2aR,2a1R,3R,5aR,8aR)-3-methoxy-2a1,6,6-trimethyl-2a,2a1,3,5a,6,7,8,8a-octahydro-2H-naphtho[1,8-bc]furan-2-one

2,2-二甲基戊二酸二甲酯

2,2-二甲基戊二酸二甲酯

(3aS,3a1S,5aR,6S,6aR,9aS,9bS)-1,1,3a1,8,8-pentamethyl-6-((methylthio)methyl)decahydro-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one

(3aS,3a1S,5aR,6S,6aR,9aS,9bS)-1,1,3a1,8,8-pentamethyl-6-((methylthio)methyl)decahydro-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one

5-((4Z,6E)-7-methoxy-3,3-dimethylhepta-4,6-dien-1-yl)-4-methylfuran-2(5H)-one

5-((4Z,6E)-7-methoxy-3,3-dimethylhepta-4,6-dien-1-yl)-4-methylfuran-2(5H)-one

1alpha,6beta,7beta,9alpha-四羟基-8,13-环氧-赖百当-14-烯-11-酮

1alpha,6beta,7beta,9alpha-四羟基-8,13-环氧-赖百当-14-烯-11-酮

5-(4-hydroxy-7-methoxy-3,3-dimethylhept-5-yn-1-yl)-4-methylfuran-2(5H)-one

5-(4-hydroxy-7-methoxy-3,3-dimethylhept-5-yn-1-yl)-4-methylfuran-2(5H)-one

上游原料

(2aR,2a1R,3R,5aR,8aR)-3-methoxy-2a1,6,6-trimethyl-2a,2a1,3,5a,6,7,8,8a-octahydro-2H-naphtho[1,8-bc]furan-2-one 2,2-二甲基戊二酸二甲酯 (3aS,3a1S,5aR,6S,6aR,9aS,9bS)-1,1,3a1,8,8-pentamethyl-6-((methylthio)methyl)decahydro-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one 5-((4Z,6E)-7-methoxy-3,3-dimethylhepta-4,6-dien-1-yl)-4-methylfuran-2(5H)-one 1alpha,6beta,7beta,9alpha-四羟基-8,13-环氧-赖百当-14-烯-11-酮 5-(4-hydroxy-7-methoxy-3,3-dimethylhept-5-yn-1-yl)-4-methylfuran-2(5H)-one (3aR,5aS,6S,9aS,9bS)-2,2,4,5a,9,9-hexamethyl-5-((trityloxy)methyl)-3a,5a,6,7,8,9,9a,9b-octahydronaphtho[1,2-d][1,3]dioxol-6-ol (1R)-5-((tert-butyldiphenylsilyl)oxy)-1-((3aS,3bR,6aR,6bR,7S,10aS,10bS)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,2,3b,6b,10,10-hexamethyloctahydronaphtho[1,2-d:3,4-d']bis([1,3]dioxole)-6a(3bH)-yl)pent-2-yn-1-ol (3aR,3bS,5R,7aR,7bS,8R,11aR,11bR)-7a-hydroxy-5-(2-hydroxyethyl)-8-((4-methoxybenzyl)oxy)-2,2,3b,5,7b,11,11-heptamethyldodecahydro-7H-benzo[f][1,3]dioxolo[4,5-h]chromen-7-one (2aR,2a1S,3S,4R,5S,5aS,8aS)-4,5-dihydroxy-2a1,6,6-trimethyl-3-((methylthio)methyl)decahydro-2H-naphtho[1,8-bc]furan-2-one (3aR,3bS,5S,7aR,7bS,8R,11aR,11bR)-7a-hydroxy-8-((4-methoxybenzyl)oxy)-2,2,3b,5,7b,11,11-heptamethyl-5-(2-((2-nitrophenyl)selanyl)ethyl)dodecahydro-7H-benzo[f][1,3]dioxolo[4,5-h]chromen-7-one (3aS,3a1S,5aR,6S,6aR,9aS,9bS)-1,1,3a1,8,8-pentamethyl-6-((methylsulfinyl)methyl)decahydro-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one (3aR,3bS,5R,7aR,7bS,8R,11aR,11bR)-5-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-7a-hydroxy-8-((4-methoxybenzyl)oxy)-2,2,3b,5,7b,11,11-heptamethyldodecahydro-7H-benzo[f][1,3]dioxolo[4,5-h]chromen-7-one (3aR,5aS,6S,9aS,9bS)-5-(hydroxymethyl)-2,2,4,5a,9,9-hexamethyl-3a,5a,6,7,8,9,9a,9b-octahydronaphtho[1,2-d][1,3]dioxol-6-ol 5-((tert-butyldiphenylsilyl)oxy)-1-((3aR,4S,5R,5aS,6R,9aR,9bR)-4,5-dihydroxy-6-((4-methoxybenzyl)oxy)-2,2,4,5a,9,9-hexamethyldecahydronaphtho[1,2-d][1,3]dioxol-5-yl)-3-methylpent-2-en-1-one (3aR,4S,5S,5aS,6R,9aR,9bR)-5-Hydroxymethyl-6-(4-methoxy-benzyloxy)-2,2,4,5a,9,9-hexamethyl-decahydro-naphtho[1,2-d][1,3]dioxole-4,5-diol 5-((4E,6Z)-7-methoxy-3,3-dimethylhepta-4,6-dien-1-yl)-4-methylfuran-2(5H)-one (2aS,2a1S,5aS,8aS)-3-methoxy-2a1,6,6-trimethyl-3-((methylthio)methyl)hexahydro-2H-naphtho[1,8-bc]furan-2,4,5(2a1H,5aH)-trione ((3aR,3bS,6aS,6bS,7R,10aR,10bR)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,2,3b,6b,10,10-hexamethyldecahydronaphtho[1,2-d:3,4-d']bis([1,3]dioxole)-6a-yl)methyl acetate (3aR,3bS,5S,7aR,7bS,8R,11aR,11bR)-7a,8-dihydroxy-2,2,3b,5,7b,11,11-heptamethyl-5-vinyldodecahydro-7H-benzo[f][1,3]dioxolo[4,5-h]chromen-7-one (2aS,2a1S,3R,4R,5R,5aS,8aS)-4,5-dihydroxy-3-methoxy-2a1,6,6-trimethyldecahydro-2H-naphtho[1,8-bc]furan-2-one (3aR,4S,5S,5aS,6R,9aR,9bR)-6-((4-methoxybenzyl)oxy)-2,2,4,5a,9,9-hexamethyl-5-((trityloxy)methyl)decahydronaphtho[1,2-d][1,3]dioxole-4,5-diol 4,4-dimethyl-5-(tetrahydro-2H-pyran-2-yloxy)pentanal 5-((4E,6E)-7-methoxy-3,3-dimethylhepta-4,6-dien-1-yl)-4-methylfuran-2(5H)-one 乙酸酐 (3aβ,,6aα,9aα,9bβ,9cβ)-1,2,3,3a,6a,9a,9b,9c-Octahydro-1,1,6,8,8,9c-hexamethyl-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one rac-5-((tert-butyldiphenylsilyl)oxy)-1-((3aR,3bS,6aR,6bS,7R,10aR,10bR)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,2,3b,6b,10,10-hexamethyloctahydronaphtho[1,2-d:3,4-d']bis([1,3]dioxole)-6a(3bH)-yl)pent-2-yn-1-one (3aβ,5aβ,6aα,9aα,9bα,9cβ)-Decahydro-1,1,8,8,9c-pentamethyl-6-methylene-5H-furo[4',3',2':4,5]naphtho[1,2-d][1,3]dioxol-5-one (3aR,3bS,5S,7aR,7bS,8R,11aR,11bR)-7a-hydroxy-8-((4-methoxybenzyl)oxy)-2,2,3b,5,7b,11,11-heptamethyl-5-vinyldecahydro-3aH-benzo[f][1,3]dioxolo[4,5-h]chromen-7(3bH)-one rac-5-((tert-butyldiphenylsilyl)oxy)-1-((3aR,3bS,6aR,6bS,7R,10aR,10bR)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,2,3b,6b,10,10-hexamethyloctahydronaphtho[1,2-d:3,4-d']bis([1,3]dioxole)-6a(3bH)-yl)-3-methylpent-2-en-1-one (3aR,4S,5S,5aS,6R,9aR,9bR)-2,2,4,5a,9,9-hexamethyl-5-((trityloxy)methyl)decahydronaphtho[1,2-d][1,3]dioxole-4,5,6-triol (2aR,3S,5aS,8aS,8bS)-6,6,8b-Trimethyl-3-methylsulfanylmethyl-octahydro-naphtho[1,8-bc]furan-2,4,5-trione 2,2-dimethyl-4-(3-methyl-5-oxo-2,5-dihydrofuran-2-yl)butanal 5-(4-hydroxy-7-methoxy-3,3-dimethylhept-5-en-1-yl)-4-methylfuran-2(5H)-one Carbonic acid (E)-1-[1,1-dimethyl-3-(3-methyl-5-oxo-2,5-dihydro-furan-2-yl)-propyl]-4-methoxy-but-2-enyl ester methyl ester (3aS,3bR,6aS,6bR,7S,10aS,10bS)-5-methoxy-7-((4-methoxybenzyl)oxy)-2,2,3b,6b,10,10-hexamethyloctahydronaphtho[1,2-d:3,4-d']bis([1,3]dioxole)-6a(3bH)-carbaldehyde