化合物简介
Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City. Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.
基本信息
中文名称
醋酸氟轻松
英文名称
fluocinolone acetonide
中文别名
乙酸肤轻松、醋酸肤轻松、肤轻松、氟轻松、仙乃乐、6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione、11b-羟基-16a,17-[(1-甲基亚乙基)-双(氧)]-21-(乙酰氧基)-6a,9-二氟孕甾-1,4-二烯-3,20-二酮
英文别名
Fluocinolone acetonide、Fluocinolone Acetonide
CAS号
67-73-2
分子式
C24H30F2O6
分子量
452.488
精确质量
452.201
PSA
93.06
LOGP
2.3668
编号系统
UNII
0CD5FD6S2M
物化性质
密度
1.36g/cm3
沸点
579ºC
熔点
267-269°C(lit.)
折射率
103 ° (C=1, MeOH)
储存条件
Keep tightly closed. Store in a cool dry place.
安全信息
RTECS号
TU3830000
安全说明
S26-S36-S22
WGK Germany
3
危险类别码
R20/21/22; R36/37/38; R40
海关编码
2937210000
危险品标志
Xn
生产方法及用途
用途
为外用皮质激素,涂于皮肤患处,治疗皮肤过敏而引起瘙痒,粘膜的炎症,神经性皮炎、接触皮炎、日光性皮炎、牛皮癣等,特别适合用于婴儿湿疹,且疗效显著,副作用少,奏效快,止痒效果好。
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