化合物简介
Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). GBR-12909 binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine, but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects. Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel. It is possible to see that the structure is based on Flunamine.
基本信息
中文名称
伐诺司林二盐酸盐
英文名称
vanoxerine dihydrochloride
中文别名
1-(2-[双(4-氟苯基)甲氧基]乙基)-4-(3-苯基丙基)哌嗪二盐酸盐、伐洛司林二盐酸盐
英文别名
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride、Vanoxerine hydrochloride、Vanoxerine dihydrochloride、I 893、1-[2-[bis(4-fluorophenyl)methoxy]-ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride
CAS号
67469-78-7
分子式
C28H34Cl2F2N2O
分子量
523.485
精确质量
522.202
PSA
15.71
LOGP
6.801
编号系统
MDL号
MFCD00055193
物化性质
外观与性状
白色固体
沸点
542.7ºC at 760 mmHg
闪点
282ºC
合成路线
