化合物简介
Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from Streptomyces sp. ME 98-M3. It specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase M/N), bacterial leucyl aminopeptidase (Aeromonas proteolytica aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase A), as well as other aminopeptidases. It does not inhibit arginyl aminopeptidase (aminopeptidase B). Amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. It also inhibits the degradation of met-enkephalin, dynorphin A, and other endogenous peptides.
基本信息
中文名称
N-[(2S,3R)-3-氨基-2-羟基-5-甲基-1-氧代己基]-L-缬氨酰-L-缬氨酰-L-天冬氨酸
英文名称
amastatin
中文别名
英文别名
AMASTATIN,STREPTOMYCES SPECIES
CAS号
67655-94-1
分子式
C21H38N4O8
分子量
474.548
精确质量
474.269
PSA
208.15
LOGP
0.9194
编号系统
EINECS号
614-098-3
物化性质
密度
1.228g/cm3
沸点
795.1ºC at 760 mmHg
闪点
434.7ºC
折射率
1.523
安全信息
危险品标志
Xi
上游原料
共找到11个上游原料 >