化合物简介
Carbadox is a veterinary drug that combats bacterial infection in swine, particularly swine dysentery. In early 2004, it was banned by the Canadian government as a livestock feed additive and for human consumption, since it is carcinogenic and induces birth defects, as was shown in animal experiments.[not in citation given] The European Union also forbids the use of carbadox at any level. It is approved in the United States for use in swine for up to 42 days before slaughter, but in 2016, the United States Food and Drug Administration moved to ban its use in pork, citing a potential cancer risk to humans. Australia forbids the use of carbadox in food producing animals.
基本信息
中文名称
卡巴多
英文名称
Carbadox
中文别名
卡巴氧、2-(喹喔啉-2-亚甲基)肼-羧酸甲酯-N,N\'-二氧化物、2(2-喹啉基-1,1-亚甲基)肼基甲酸甲酯、N,N’-二氧化甲基(2-喹喔啉基亚甲基)肼羧酸酯
英文别名
methyl 3-(2-quinoxalinylmethylene)carbazate N1,N4-dioxide、Mecadox、CARBADO、gs6244、getroxel、karbadox、carabadox、methyl-3-(2-quinoxalinylmethylene)carbazate N,N\'-dioxide、fortigro、Mecadox-S、(1,4-dioxy-quinoxalin-2-ylmethylene)-hydrazinecarboxylic acid methyl ester
CAS号
6804-07-5
分子式
C11H10N4O4
分子量
262.222
精确质量
262.07
PSA
101.61
LOGP
1.7776
编号系统
MDL号
MFCD00057293
物化性质
密度
1.447g/cm3
熔点
239-240ºC
折射率
1.648
储存条件
2-8ºC
安全信息
RTECS号
FE2779000
安全说明
S53-S45
WGK Germany
3
危险类别码
R45; R11; R22
危险品运输编码
UN 1325 4.1/PG 2
危险品标志
F
生产方法及用途
用途
卡巴氧又名卡巴多、卡巴得、痢立清、喹肼脂、是喹口恶森类生长促进剂中代性品种。卡巴氧抗菌谱较广,对革兰氏阻性菌(例如大肠杆菌、沙门氏杆菌、志贺氏菌及变形杆菌)特别敏感;对革兰氏阳性菌(例如葡萄球菌、链球菌)的最小抑菌浓度也优于金霉素,因而卡巴得能有效控制猪赤痢脏乱细菌性下痢。卡巴得具有蛋白同化作用,对促进猪的生长及改善饲料转化率具有显著的效果。