化合物简介
Fialuridine, or 1-(2-deoxy-2-fluoro-1-D-arabinofuranosyl)-5-iodouracil (FIAU), is a nucleoside analogue that was investigated as a potential therapy for hepatitis B virus infection. In a 1993 clinical study at the NIH, unexpected toxicity led to the death of 5 out of 15 patients from liver failure associated with lactic acidosis; two further participants required liver transplantation. This toxicity was unusual in that it was not predicted by animal studies. It is suspected that the drug's toxicity was due to its damaging mitochondria.
基本信息
中文名称
非阿尿苷
英文名称
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
中文别名
5-碘-2\'-氟脱氧尿苷、1-[(2R,3S,4R,5R)-3-氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]-5-碘嘧啶-2,4-二酮、1-(2-脱氧-2-氟-β-D-阿拉伯呋喃基)-5-碘尿嘧啶
英文别名
1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
CAS号
69123-98-4
分子式
C9H10FIN2O5
分子量
372.089
精确质量
371.962
PSA
104.55
LOGP
-1.2701
编号系统
MDL号
MFCD00866922
物化性质
外观与性状
无色晶体
密度
2.18 g/cm3
熔点
216-217ºC
折射率
1.685
安全信息
海关编码
2934999090
上游原料
共找到7个上游原料 >