百科

除莠霉素A

除莠霉素A

CAS号：70563-58-5

英文名：herbimycin

分子式

C30H42N2O9

熔点

密度

1.19 g/cm3

分子量

574.662

沸点

752.4ºC at 760 mmHg

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

基本信息

中文名称

除莠霉素A

英文名称

herbimycin

中文别名

英文别名

(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate、(15R)-17-demethoxy-15-methoxy-11-O-methylgeldanamycin、Herbimycin A、(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione、HERBIMYCIN A

CAS号

70563-58-5

分子式

C30H42N2O9

分子量

574.662

精确质量

574.289

PSA

152.48

LOGP

3.7424

编号系统

MDL号

MFCD00151702

PubChem号

24895756

BRN号

4834067

RTECS号

LX8930000

物化性质

外观与性状

黄色粉末

密度

1.19 g/cm3

沸点

752.4ºC at 760 mmHg

闪点

408.8ºC

折射率

1.545

储存条件

-20ºC

安全信息

安全说明

S22; S24/25; S36; S26

危险类别码

R36/37/38

海关编码

29419000

危险品标志

Xi

合成路线

145798-89-6

除莠霉素A

上游原料

共找到61个上游原料 >

(2S,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethyl-1-heptanol

(2S,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethyl-1-heptanol

(E)-(3S,4S,7S,8R,9S,11S,12R)-12-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-3,8,9,12-tetramethoxy-5,7,11-trimethyldodeca-1,5-dien-4-yl acrylate

(E)-(3S,4S,7S,8R,9S,11S,12R)-12-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-3,8,9,12-tetramethoxy-5,7,11-trimethyldodeca-1,5-dien-4-yl acrylate

(2R,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethylheptanal

(2R,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethylheptanal

(3S)-3-甲基-4-{[(2-甲基-2-丙基)(二苯基)硅烷基]氧基}丁醛

(3S)-3-甲基-4-{[(2-甲基-2-丙基)(二苯基)硅烷基]氧基}丁醛

ethyl (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-15-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-7-hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethylpentadeca-2,4,8-trienoate

ethyl (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-15-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-7-hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethylpentadeca-2,4,8-trienoate

5-(tert-butyl-dimethyl-silanyloxy)-13-(2,5-dimethoxy-3-nitro-phenyl)-4,9,10,13-tetramethoxy-6,8,12-trimethyl-trideca-2,6-dienal

5-(tert-butyl-dimethyl-silanyloxy)-13-(2,5-dimethoxy-3-nitro-phenyl)-4,9,10,13-tetramethoxy-6,8,12-trimethyl-trideca-2,6-dienal

上游原料

(2S,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethyl-1-heptanol (E)-(3S,4S,7S,8R,9S,11S,12R)-12-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-3,8,9,12-tetramethoxy-5,7,11-trimethyldodeca-1,5-dien-4-yl acrylate (2R,3R,4S,6S)-3,4-dimethoxy-7-((4-methoxybenzyl)oxy)-2,6-dimethylheptanal (3S)-3-甲基-4-{[(2-甲基-2-丙基)(二苯基)硅烷基]氧基}丁醛 ethyl (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-15-[3-bis(tert-butoxycarbonyl)amino-2,5-dimethoxyphenyl]-7-hydroxy-6,11,12,15-tetramethoxy-2,8,10,14-tetramethylpentadeca-2,4,8-trienoate 5-(tert-butyl-dimethyl-silanyloxy)-13-(2,5-dimethoxy-3-nitro-phenyl)-4,9,10,13-tetramethoxy-6,8,12-trimethyl-trideca-2,6-dienal 5-(tert-butyl-dimethyl-silanyloxy)-13-(2,5-dimethoxy-3-nitro-phenyl)-4,9,10,13-tetramethoxy-6,8,12-trimethyl-trideca-2,6-dien-1-ol 3-bromo-2,5-dimethoxyaniline 3-(tert-butyl-dimethyl-silanyl)-11-(2,5-dimethoxy-3-nitro-phenyl)-2,7,8,11-tetramethoxy-4,6,10-trimethyl-undec-4-enal (4R,6S)-7-(tert-butyldiphenylsilyloxy)-6-methylhept-1-en-4-ol (2R,3R,4S,6S,7R)-7-(2,5-dimethoxy-3-nitrophenyl)-3,4,7-trimethoxy-2,6-dimethylheptanal 12-(2,5-dimethoxy-3-nitro-phenyl)-3,8,9,12-tetramethoxy-5,7,11-trimethyl-dodeca-1,5-diene-4-ol 9-(tert-butyl-dimethyl-silanyloxy)-8,13,14,17,20,22-hexamethoxy-4,10,12,16-tetramethyl-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-3-one (E)-(4S,5R,6S,8S,9R)-9-(2,5-Dimethoxy-3-nitro-phenyl)-5,6,9-trimethoxy-2,4,8-trimethyl-non-2-en-1-ol (E)-(3S,4S,7S,8R,9S,11S)-12-tert-butyldiphenylsilyloxy-3,8,9-trimethoxy-5,7,11-trimethyldodec-1,5-dien-4-ol 1-溴-2,5-二甲氧基-3-硝基苯 N-(triphenylmethyl)-3-bromo-2,5-dimethoxyaniline (2R,3S,5S,6R)-2-Benzyloxy-6-(2,5-dimethoxy-3-nitro-phenyl)-6-methoxy-5-methyl-hexane-1,3-diol (4R,6S)-7-tert-butyldiphenylsilyloxy-4-methoxy-6-methylhept-2-ene (4S,5R,6S,8S,9R,E)-9-(2,5-dimethoxy-3-nitrophenyl)-5,6,9-trimethoxy-2,4,8-trimethylnon-2-enal 4-甲氧基-2-硝基酚 (E)-(1R,2S,4S,5R,6S,9S,10S)-9-tert-butyldimethylsilyloxy-1-(3-diallylamino-2,5-dimethoxyphenyl)-4,5,10-trimethoxy-2,6,8-trimethyldodec-7,11-dien-1-ol (2R,3S,5S,6R)-2-(benzyloxy)-1-((tert-butyldimethylsilyl)oxy)-6-(2,5-dimethoxy-3-nitrophenyl)-6-methoxy-5-methylhexan-3-ol (E)-(3S,4S,7S,8R,9S,11S)-4-tert-butyldimethylsilyloxy-12-tert-butyldiphenylsilyloxy-3,8,9-trimethoxy-5,7,11-trimethyldodec-1,5-diene 2-溴-4-甲氧基-6-硝基苯酚 ethyl (2E,4Z,6S,7S,8E,10S,11R,12S,14S,15R)-7-<(t-butyldimethylsilyl)oxy>-15-<2,5-dimethoxy-3-<(triphenylmethyl)amino>phenyl>-6,11,12,15-tetramethoxy-2,8,10,14-tetramethyl-2,4,8-pentadecatrienoate (2E,4S,5R,6S,8S)-5,6-dimethoxy-9-[(4-methoxybenzyl)oxy]-2,4,8-trimethyl-2-nonenal (2S,4S,5R,6S,7E,9S,10S)-9-((t-butyldimethylsilyl)oxy)-4,5,10-trimethoxy-2,6,8-trimethyl-7,11-dodecadien-1-ol (3S,4R,5S,7S)-8-tert-butyldiphenylsilyloxy-4,5-dimethoxy-3,7-dimethyloct-1-ene tert-butyl(((3S,4S,7S,8R,9S,11S,12R,E)-12-(2,5-dimethoxy-3-nitrophenyl)-3,8,9,12-tetramethoxy-5,7,11-trimethyldodeca-1,5-dien-4-yl)oxy)dimethylsilane 5-(tert-butyl-dimethyl-silanyloxy)-13-(2,5-dimethoxy-3-nitro-phenyl)-4,9,10,13-tetramethoxy-6,8,12-trimethyl-trideca-2,6-dienoic acid methyl ester tert-butyl((2S,4R)-4-methoxy-2-methylhept-6-enyloxy)diphenylsilane (E)-(5S,6R,7S,9S,10R)-10-(2,5-Dimethoxy-3-nitro-phenyl)-6,7,10-trimethoxy-5,9-dimethyl-dec-3-enoic acid methyl ester (4S,5R,6S,8S,9R,E)-ethyl 9-(2,5-dimethoxy-3-nitrophenyl)-5,6,9-trimethoxy-2,4,8-trimethylnon-2-enoate (2R,3S,5S,6R)-2-(benzyloxy)-6-(2,5-dimethoxy-3-nitrophenyl)-3,6-dimethoxy-5-methylhexan-1-ol (2S,4S,5R)-5-(2,5-dimethoxy-3-nitrophenyl)-2,5-dimethoxy-4-methylpentanal (3S,4R,5S,7S)-8-tert-butyldiphenylsilyloxy-5-methoxy-3,7-dimethyloct-1-en-4-ol (2S,4S,5R,6S,7E,9S,10S)-9-((t-butyldimethylsilyl)oxy)-4,5,10-trimethoxy-2,6,8-trimethyl-7,11-dodecadienal N,N-diallyl-3-bromo-2,5-dimethoxyaniline (E)-(4S,5R,6S,8S)-9-tert-butyldiphenylsilyloxy-5,6-dimethoxy-2,4,8-trimethylnon-2-enal [(2R,3S,5S,6R)-2-Benzyloxy-6-(2,5-dimethoxy-3-nitro-phenyl)-3,6-dimethoxy-5-methyl-hexyloxy]-tert-butyl-dimethyl-silane