百科

洋地黄毒苷

洋地黄毒苷

CAS号：71-63-6

英文名：digitoxin

分子式

C41H64O13

熔点

240ºC (dec.)(lit.)

密度

1.33 g/cm3

分子量

764.939

沸点

902.3ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

Digitoxin is a cardiac glycoside. It is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.

基本信息

中文名称

洋地黄毒苷

英文名称

digitoxin

中文别名

洋地黄毒甙

英文别名

tridigitoxosyldigitoxigenin、Ditaven、digicor、[3H]-Digitoxin、Natigal、Acedoxin、Myodigin、DIGITOXIN、Digimed、Digitrin、Cardigin、Card-20(22)-enolide, 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-β-D, 14-dihydroxy-、Digilong、De-Tone

CAS号

71-63-6

分子式

C41H64O13

分子量

764.939

精确质量

764.435

PSA

182.83

LOGP

3.2473

编号系统

UNII

E90NZP2L9U

物化性质

外观与性状

白色粉末

密度

1.33 g/cm3

沸点

902.3ºC at 760 mmHg

熔点

240ºC (dec.)(lit.)

闪点

269.5ºC

折射率

1.593

储存条件

库房低温,通风,干燥,与食品原料分开存放

安全信息

RTECS号

IH2275000

安全说明

S45

WGK Germany

3

危险类别码

R23/25; R33

危险品运输编码

UN 2811

危险类别

6.1(a)

包装等级

II

危险品标志

T

危险标志

GHS06, GHS08

危险性描述

H301; H331; H373

信号词

Danger

危险性防范说明

P261; P301 + P310; P311

生产方法及用途

生产方法

1.通常以洋地黄叶为原料提取。工艺路线如下：洋地黄叶去杂干燥粉碎H2O28～35℃发酵过滤叶粉70%乙醇浸提过滤滤液浓缩去胶4～6h氯仿提取分离氯仿提取液水洗5%NaOH洗涤水洗浓缩黏稠物丙酮热溶冷却静置0～5℃过滤粗品柱色谱纯化产品

用途

能加强心肌收缩力、减慢心率和抑制传导。适用于慢性心功能不全患者长期服用。

合成路线

共找到11条合成路线 >

digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside

digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside

洋地黄毒苷

洋地黄毒苷

上游原料

共找到34个上游原料 >

digitoxigen O-[2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)

digitoxigen O-[2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside)

(2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester

(2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester

1,2,4,6-tetra-O-acetyl-3-O-benzylallopyranose

1,2,4,6-tetra-O-acetyl-3-O-benzylallopyranose

digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside

digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside

(((2R,3R,4S,6S)-4-(benzyloxy)-6-(((2R,3R,4R,5R,6R)-4-(benzyloxy)-5-methoxy-2-methyl-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)(tert-butyl)dimethylsilane

(((2R,3R,4S,6S)-4-(benzyloxy)-6-(((2R,3R,4R,5R,6R)-4-(benzyloxy)-5-methoxy-2-methyl-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)(tert-butyl)dimethylsilane

phenyl 3-O-benzyl-2,6-dideoxy-β-D-ribo-hexapyranosyl-(1→4)-3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribo-hexopyranoside

phenyl 3-O-benzyl-2,6-dideoxy-β-D-ribo-hexapyranosyl-(1→4)-3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribo-hexopyranoside

下游产品

共找到11个下游商品 >

N-cyclopentyl-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]thiadiazole-4-carboxamide

N-cyclopentyl-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]thiadiazole-4-carboxamide

地黄苷元

(5beta)-12,beta,14-二羟基-3-氧代心甾-20(22)-烯内酯

(5beta)-12,beta,14-二羟基-3-氧代心甾-20(22)-烯内酯

毛地黄毒苷配基

毛地黄毒苷配基

乙酰洋地黄毒甙

乙酰洋地黄毒甙

4-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮

4-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮

上游原料

digitoxigen O-[2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside) (2R,3R,4S)-4-(tert-butyldimethylsiloxy)-hex-5-yne-2,3-diol 2-benzoate ester 1,2,4,6-tetra-O-acetyl-3-O-benzylallopyranose digitoxigen O-[2'',6''-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside (((2R,3R,4S,6S)-4-(benzyloxy)-6-(((2R,3R,4R,5R,6R)-4-(benzyloxy)-5-methoxy-2-methyl-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)(tert-butyl)dimethylsilane phenyl 3-O-benzyl-2,6-dideoxy-β-D-ribo-hexapyranosyl-(1→4)-3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribo-hexopyranoside digitoxigen 3-O-acetyl-2,6-dideoxy-4-O-((2'R,6'R)-3',6'-dihydro-6'-methyl-2H-pyran-2'-yl)-β-D-ribo-hexopyranoside 乙酰洋地黄毒甙 digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside) digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-5'',6''-dihydro-6''-methyl-5''-oxo-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside) (21',23'-epoxy-14'-hydroxy-24'-nor-5'β,14'β-chola-10',22'-dien-3'β-yl) O-<2''',6'''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-O-<2'',6''-dideoxy-β-D-ribo-hexopyranosyl>-(1->4)-<2,6-dideoxy-β-D-ribo-hexopyranoside> 3,4-bis-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-enitol digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-3'',6''-dihydro-6''-methyl-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside) (2R,3R,4S)-3-(((2S,4S,5R,6R)-4,5-bis((tert-butyldimethylsilyl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-ol 4-O-[3,4-bis-(tert-butyldimethylsilyl)-2,6-dideoxy-β-D-allopyranosyl]-3-(tert-butyldimethylsilyl)-1,5-anhydro-2,6-dideoxy-D-ribo-hex-1-entol (2R,3S,4S,6S)-6-(((2R,3R,4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(((2R,3R,4S)-4-((tert-butyldimethylsilyl)oxy)-2-methyl-3,4-dihydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diol 毛花洋地黄苷A phenyl 3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribohexopyranoside (2R,3R,4S)-3-(((2S,4S,5R,6R)-4,5-bis((tert-butyldimethylsilyl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-((tert-butyldimethylsilyl)oxy)hex-5-yn-2-yl benzoate digitoxigen O-[3'-O-acetyl-2',6'-dideoxy-4'-O-((2''R,6''R)-5'',6''-dihydro-6''-methyl-5''-hydroxyl-2H-pyran-2''-yl)-β-D-ribo-hexopyranosyl]-(1->4)-(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranoside) (2R,3R,4S,6S)-4-(benzyloxy)-6-(((2R,3R,4S,6S)-4-(benzyloxy)-6-(((2R,3R,4R,5R,6R)-4-(benzyloxy)-5-methoxy-2-methyl-6-(phenylthio)tetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-ol (5R)-1-hydroxy-5-tert-butyldimethylsilanyloxymethyl-5H-pyran-4-(1H)-one phenyl 3-O-benzyl-4-O-tert-butyldimethylsilyl-2,6-dideoxy-β-D-ribohexapyranosyl-(1→4)-3-O-benzyl-2,6-dideoxy-β-D-ribo-hexapyranosyl-(1→4)-3-O-benzyl-6-deoxy-2-O-methyl-1-thio-α-D-ribohexopyranoside 2,6-dideoxy-3,4-bis-O-(triethylsilyl)-β-D-ribohexapyranosyl-(1→4)-2,6-dideoxy-3-O-triethylsilyl-β-D-ribo-hexapyranosyl-(1→4)-1,5-anhydro-2,6-dideoxy-3-O-triethylsilyl-D-ribo-hex-1-enitol (2R,3R,4S,6S)-6-(((2R,3R,4S)-4-((tert-butyldimethylsilyl)oxy)-2-methyl-3,4-dihydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate Carbonic acid, (2S,6R)-5,6-dihydro-6-methyl-5-oxo-2H-pyran-2-yl 1,1-dimethylethyl ester phenyl 3-O-benzyl-2-O-methyl-6-O-p-toluenesulfonyl-1-thio-α-D-ribohexopyranoside (2R,3R,4S,6S)-6-(((2R,3R,4S,6S)-4-((tert-butyldimethylsilyl)oxy)-6-(((2R,3R,4S)-4-((tert-butyldimethylsilyl)oxy)-2-methyl-3,4-dihydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate

下游产品

N-cyclopentyl-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]thiadiazole-4-carboxamide 地黄苷元 (5beta)-12,beta,14-二羟基-3-氧代心甾-20(22)-烯内酯毛地黄毒苷配基乙酰洋地黄毒甙 4-[(5R,10S,13R,14S,17R)-14-羟基-10,13-二甲基-3-氧代-2,4,5,6,7,8,9,11,12,15,16,17-十二氢-1H-环戊并[a]菲-17-基]-5H-呋喃-2-酮 3-[(3S,5R,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one (5beta)-3beta-[(2,6-二脱氧-beta-D-核-己糖吡喃糖苷)氧基]-14-羟基心甾-20(22)-烯内酯 [(2R,3R,4S,6S)-3-[(2R,4S,5R,6R)-4-acetyloxy-5-[(2R,4S,5R,6R)-4,5-diacetyloxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-[[(3S,5R,8R,9S,10S,13R,17R)-14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclop