白三烯B4

白三烯B4

CAS号：71160-24-2

英文名：leukotriene B4

分子式

C20H32O4

熔点

密度

1.04g/cm3

分子量

336.466

沸点

536.37ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

白三烯B4（英语：Leukotriene B4）是一种与炎症反应有关的白三烯类物质。它由响应炎症介质的白细胞产生，让白细胞活化并依附在内皮上，允许其穿过组织。在中性粒细胞中，它也是一种强效化学诱导物，并且能够诱导形成活性氧类和溶酶体中酶的释放。它由白三烯A4水解酶（英语：leukotriene-A4 hydrolase）水解白三烯A4而来。类二十烷酸的合成（右侧为白三烯）

基本信息

中文名称

白三烯B4

英文名称

leukotriene B4

中文别名

[5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸、白[细胞]三烯 b4

英文别名

Leukotriene B4 Lipid Maps MS Standard、Leukotriene B4,(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoicacid、6Z,8E,10E,14Z,5S,12R-diHETE、LTB4、LEUKOTRIENE B4

CAS号

71160-24-2

分子式

C20H32O4

分子量

336.466

精确质量

336.23

PSA

77.76

LOGP

4.1583

编号系统

UNII

1HGW4DR56D

物化性质

密度

1.04g/cm3

沸点

536.37ºC at 760 mmHg

闪点

14°C

折射率

1.527

储存条件

-20ºC

安全信息

安全说明

S; S7; S16

危险类别码

R11

WGK Germany

1

危险品运输编码

UN 1170 3/PG 2

危险品标志

F

危险标志

GHS02, GHS07

危险性防范说明

P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235

信号词

Danger

危险性描述

H225; H319

合成路线

Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate

Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate

白三烯B4

上游原料

共找到167个上游原料 >

4-氯甲酰基丁酸甲酯

4-氯甲酰基丁酸甲酯

2(S)-[1'(R)-[(tert-butyldimethylsilyl)oxy]-3'(Z)-nonenyl]-3(S)-(trimethylsilyl)oxirane

2(S)-[1'(R)-[(tert-butyldimethylsilyl)oxy]-3'(Z)-nonenyl]-3(S)-(trimethylsilyl)oxirane

1-(trimethylsilyl)-1(E),5(Z)-undecadien-3(R)-ol

1-(trimethylsilyl)-1(E),5(Z)-undecadien-3(R)-ol

4(R)-[(tert-butyldiphenylsilyl)oxy]dodeca-2(E),6(Z)-dienal

4(R)-[(tert-butyldiphenylsilyl)oxy]dodeca-2(E),6(Z)-dienal

5-(tert-Butyl-diphenyl-silanyloxy)-hept-6-ynoic acid methyl ester

5-(tert-Butyl-diphenyl-silanyloxy)-hept-6-ynoic acid methyl ester

(+)-(5Z)-(3R)-5-undecen-1-yn-3-ol

(+)-(5Z)-(3R)-5-undecen-1-yn-3-ol

上游原料

4-氯甲酰基丁酸甲酯 2(S)-[1'(R)-[(tert-butyldimethylsilyl)oxy]-3'(Z)-nonenyl]-3(S)-(trimethylsilyl)oxirane 1-(trimethylsilyl)-1(E),5(Z)-undecadien-3(R)-ol 4(R)-[(tert-butyldiphenylsilyl)oxy]dodeca-2(E),6(Z)-dienal 5-(tert-Butyl-diphenyl-silanyloxy)-hept-6-ynoic acid methyl ester (+)-(5Z)-(3R)-5-undecen-1-yn-3-ol (Z)-壬-3-烯醛 methyl 5-oxo-7-trimethylsilylhept-6-ynoate 5(S)-[(tert-butyldiphenylsilyl)oxy]-12(R)-[(triethylsilyl)oxy]-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid methyl ester 2-(R),3-(S)-epoxy-cis-5-undecenal 2(S)-[1'(S)-hydroxy-3'(Z)-nonenyl]-3(S)-(trimethylsilyl)oxirane (R,Z)-1-((2R,3R)-3-(trimethylsilyl)oxiran-2-yl)non-3-en-1-ol (S,Z)-methyl 5-((tert-butyldimethylsilyl)oxy)-9-(trimethylsilyl)non-6-en-8-ynoate 9(R),12(R)-bis((tert-butyldiphenylsilyl)oxy)-10(S),11(S)-O-(1-methylethylidene)-6,14-icosadiyne-10,11-diol Methyl (5S)-7-Bromo-5-hydroxyhept-6-enoate (5S,6Z,8E,10E,12R,14Z)-methyl 5,12-bis((tert-butyldiphenylsilyl)oxy)-6,8,10,14-eicosatetraenoate (6Z,8E,10E,14Z)-(5S,12R)-5-(tert-Butyl-dimethyl-silanyloxy)-12-(tert-butyl-diphenyl-silanyloxy)-icosa-6,8,10,14-tetraenoic acid (5S,8E,10E,12R)-methyl 5,12-bis<(tert-butyldiphenylsilyl)oxy>-8,10-eicosadiene-6,14-diynoate (+)-(3E,7Z)-(5R)-5-[(tert-butyldimethylsilyl)oxy]-3,7-tridecadien-1-yne methyl 5(S)-(tert-butyldiphenylsiloxy)-10-hydroxydec-8-en-6-ynoate Methyl 5S-benzoyloxy-5-formylvalerate [6(R)-[(tert-butyldiphenylsilyl)oxy]-2(E),4(E),8(Z)-tetradecatrien-1-yl]triphenylphosphonium bromide (2E,4E,8Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trienoic acid ethyl ester 1-庚炔 (+)-(1E,5Z)-(3R)-1-iodo-3-[(tert-butyldimethylsilyl)oxy]-1,5-undecadiene 2(R)-[(tert-butyldiphenylsilyl)oxy]dec-4(Z)-enal 1-bromo-6(R)-((tert-butyldiphenylsilyl)oxy)-2(E),4(E),8(Z)-tetradecatriene (2R)-2-hydroxy-4-decynyl 4-nitrobenzoate 4-Decynal, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (R)- (R,Z)-1-((2S,3S)-3-(trimethylsilyl)oxiran-2-yl)non-3-en-1-ol methyl 5(S)-(benzoyloxy)-12(R)-hydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoate methyl 5(S)-hydroxy-7-(trimethylsilyl)-6(E)-heptenoate 6-Heptynoic acid, 5-hydroxy-, methyl ester, (5S)- 5-氧代戊酸甲酯 methyl 7-bromo-5(S)-[(tert-butyldimethylsilyl)oxy]-6(Z)-heptenoate methyl 5(S)-[(tert-butyldimethylsilyl)oxy]-6(Z)-nonen-8-ynoate (5S)-methyl 8-(dimethylphosphono)-5-[(tert-butyldiphenylsilyl)oxy]-6-octynoate (S)-5-hydroxy-7-trimethylsilylhept-6-ynoic acid methyl ester methyl (S,E)-10-bromo-5-((tert-butyldiphenylsilyl)oxy)dec-8-en-6-ynoate (2E,4R)-4-[(tert-butyldiphenylsilyl)oxy]-2-dodecen-6-ynal Methyl (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate 6(R)-[(tert-butyldiphenylsilyl)oxy]-2(E),4(E),8(Z)-tetradecatrien-1-ol (2R)-2-((tert-butyldiphenylsilyl)oxy)-4-decynyl 4-nitrobenzoate 5(S),12(R)-bis[(tert-butyldimethylsilyl)oxy]-6(7),8(E),10(E),14(Z)-eicosatetraenoic acid (5S)-methyl 5-hydroxy-8-(tetrahydropyran-2-yloxy)-6-octynoate 4-Decyn-1-ol, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (R)- (5S)-methyl 8-bromo-5-<(tert-butyldiphenylsilyl)oxy>-6-octynoate