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(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮

(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮

CAS号：714272-27-2

英文名：(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione

分子式

C19H20N4O2

熔点

密度

1.267

分子量

336.388

沸点

730.345ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Plinabulin (NPI-2358) is a 2,5-diketopiperazine derivative that is being developed as an experimental cancer drug. It is a synthetic analog of the natural compound phenylahistin. Plinabulin interrupts tumor blood flow via disruption of the tumor's vascular endothelial cells resulting in tumor necrosis. It also has a tubulin-depolymerizing activity.

基本信息

中文名称

(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮

英文名称

(3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione

中文别名

普那布林

英文别名

3-(Z)-benzylidene-6-(((Z)-5-tert-butyl-1H-imidazol-4-yl)methylene)-piperazine-2,5-dione、3-Z-benzylidene-6-(5\"-tert-butyl-1H-imidazol-4\"-Z-ylmethylene)-piperazine-2,5-dione、Plinabulin,NPI2358,NPI-2358、tert-butyl-dehydrophenylahistin、Plinabulin,NPI2358、NPI 2358、NPI-2358/KPU-2、Plinabulin、Plinabulin [USAN:INN]

CAS号

714272-27-2

分子式

C19H20N4O2

分子量

336.388

精确质量

336.159

PSA

94.92

LOGP

1.566

编号系统

MDL号

MFCD18074510

物化性质

密度

1.267

沸点

730.345ºC at 760 mmHg

闪点

395.498ºC

合成路线

1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

苯甲醛

(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮

(3Z,6Z)-3-[(5-叔丁基-1H-咪唑-4-基)亚甲基]-6-(苯亚甲基)-2,5-哌嗪二酮

上游原料

共找到12个上游原料 >

苯甲醛

1-acetyl-3-benzylidene-2,5-piperazinedione

1-acetyl-3-benzylidene-2,5-piperazinedione

3-叔丁基-4-乙氧羰基咪唑

3-叔丁基-4-乙氧羰基咪唑

2-chloro-4,4-dimethyl-3-oxopentanoic acid ethyl ester

2-chloro-4,4-dimethyl-3-oxopentanoic acid ethyl ester

sodium (S)-2-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxypropanoate

sodium (S)-2-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxypropanoate

1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione

上游原料

苯甲醛 1-acetyl-3-benzylidene-2,5-piperazinedione 3-叔丁基-4-乙氧羰基咪唑 2-chloro-4,4-dimethyl-3-oxopentanoic acid ethyl ester sodium (S)-2-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxypropanoate 1-acetyl-3-{(Z)-1-[5-(tert-butyl)-1H-4-imidazolyl]methylidene}-2,5-piperazinedione (((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate (R)-4-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxybutanoic acid (5-叔丁基-1H-咪唑-4-基)甲醇 sodium (R)-4-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxybutanoate (9ci)-5-(1,1-二甲基乙基)-1H-咪唑-4-羧醛特戊酰基乙酸乙酯