化合物简介
Reboxetine (brand names: Edronax (AU, IE, IL, NZ, ZA, UK), Prolift (AR,† BR, CL, VE†)) is a drug of the norepinephrine reuptake inhibitor class, marketed as an antidepressant by Pfizer for use in the treatment of unipolar depression, although it has also been used off-label for panic disorder and ADHD. It is approved for use in many countries worldwide, but has not been approved for use in the United States. Although its efficacy as an antidepressant has been challenged in multiple published reports, its popularity has continued to increase.
基本信息
中文名称
甲磺酸瑞波西汀
英文名称
Reboxetine mesylate
中文别名
(2R)-2-[(R)-(2-乙氧基苯氧基)苯甲基]吗啉甲磺酸盐
英文别名
(+/-)-(2S,3S)-iodoreboxetine、1-bromo-2,3-epoxy-3-phenylpropane、3-Bromomethyl-2-phenyloxirane、trans-Cinnamyl bromide epoxide、Oxirane,2-(bromomethyl)-3-phenyl、2-bromomethyl-3-phenyloxirane、trans-3-bromo-1-phenyl-1,2-epoxypropane、(+/-)-(2S,3R)-2-(bromomethyl)-3-phenyloxirane
CAS号
71620-89-8
分子式
C19H23NO3
分子量
313.391
精确质量
313.168
PSA
39.72
LOGP
3.5226
编号系统
MDL号
MFCD28142770
物化性质
外观与性状
白色固体
密度
1.113 g/cm3
沸点
443.7ºC at 760 mmHg
熔点
141-143ºC
闪点
188.2ºC
储存条件
Desiccate at +4ºC