首页
依诺沙星

依诺沙星

CAS号:74011-58-8
英文名:enoxacin
若想填写更详细的询价信息,请点击进入询价页面
点我
化合物简介
Enoxacin[note 1] is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect. It is no longer available in the United States.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
方法1:以2,6-二羟基-5-氟烟酰胺为原料,经氯化、酯化、与乙酰哌嗪缩合、与3-乙胺基丙酸乙酯缩合、环化、脱氢、水解得产品。该路线条件温和,路线较短,但需特殊试剂四氯苯醌。国内目前主要采用该法。
方法2:另一条路线是以2,6-二氯-3-硝基吡啶为原料,经与乙氧羰基哌嗪缩合后,再经氨解、乙酰化、还原、重氮化、氟化、水解、与EMME缩合、环合乙基化、水解得产品。该法氟化反应不易控制、环化需高温,工艺条件苛刻。
用途
抗感染药,用来抗菌消炎。
国家/地区名称
海关编码
更新时间
操作
中国293359952019-03查看
上游原料
2-chloro-5-fluoro-6-(p-tolylthio)nicotinonitrile ethyl 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethoxycarbonyl-1-piperazinyl)-1,8-naphthyridine-3-carboxylate 2,5-difluoro-6-(4-methylphenyl)sulfanylpyridine-3-carbonitrile ethyl 2-[N-ethyl-N-(2-ethoxycarbonyl)ethyl]amino-5-fluoro-6-(p-tolylthio)nicotinate ethyl 7-(4-(ethoxycarbonyl)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate ethyl 2,5-difluoro-6-(p-tolylthio)nicotinate 2-[N-ethyl-N-(2-ethoxycarbonyl)ethyl]amino-5-fluoro-6-(p-tolylthio)nicotinonitrile ethyl 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate ethyl 1-ethyl-6-fluoro-1,2-dihydro-4-hydroxy-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate ethyl 4-(6-amino-3-nitropyridin-2-yl)piperazine-1-carboxylate 6-acetylamino-2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoropyridine ethyl 4-(6-amino-3-fluoropyridin-2-yl)piperazine-1-carboxylate ethyl 4-(6-acetamido-3-nitropyridin-2-yl)piperazine-1-carboxylate 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylic acid ethyl 4-(6-acetamido-3-aminopyridin-2-yl)piperazine-1-carboxylate diethyl N-[2-(4-ethoxycarbonyl-1-piperazinyl)-3-fluoro-6-pyridinyl]aminomethylenemalonate 3-氰基-2,6-二氯-5-氟吡啶 N-乙基-beta-丙氨酸乙酯 2,5-difluoro-6-(4-methylphenyl)sulfanylpyridine-3-carboxamide ethyl 4-(6-chloro-3-nitropyridin-2-yl)piperazine-1-carboxylate 哌嗪 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylsulfonyl)-1,8-naphthyridine-3-carboxylic acid ethyl 4-amino-1-ethyl-6-fluoro-1,2-dihydro-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate 7-(4-ethoxycarbonyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid