化合物简介
Spirorenone (INN) (developmental code name ZK-35973) is a steroidal antimineralocorticoid of the spirolactone group that was never marketed. Spirorenone possesses 5–8 times the antimineralocorticoid activity of spironolactone in animal studies. The initial discovery of spirorenone was deemed a great success, as no compound with greater antimineralocorticoid activity had been developed since spironolactone in 1957. Moreover, spirorenone itself has virtually no affinity for the androgen receptor while its progestogenic activity shows species differences, being somewhat greater than that of spironolactone in rabbits but absent in mice and rats. As such, it was characterized as a highly potent antimineralocorticoid with far fewer hormonal side effects relative to spironolactone.
基本信息
中文名称
螺利酮
英文名称
spirorenone
中文别名
英文别名
(6R,7R,8R,9S,10R,13S,14R,15S,16S,17S)-3\',4\',6,7,8,9,11,12,13,14,15,16,20,21-Tetradecahydro-10,13-dimethylspiro(17H-dicyclopropa(6,7:15,16)cyclopenta(A)phenanthrene-17,2\'(5\'H)-furan)-3(10H),5\'-dione、Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(A)phenanthrene-17,2\'(5\'H)-furan)-3,5\'(10H)-dione,3\',4\',6,7,8,9,11,12,13,14,15,16,20,21-tetradecahydro-10,13-dimethyl-,(6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta))、Spirorenonum [inn-latin]、Spirorenonum、Espirorenona、Espirorenona [inn-spanish]
CAS号
74220-07-8
分子式
C24H28O3
分子量
364.477
精确质量
364.204
PSA
43.37
LOGP
4.0819
编号系统
EINECS号
277-770-1
物化性质
密度
1.28g/cm3
沸点
556.1ºC at 760 mmHg
闪点
243.7ºC
折射率
1.627
上游原料
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