化合物简介
Piracetam (sold under many brand names) is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid. Piracetam is a cyclic derivative of GABA. Presently piracetam is used in many European countries, Asia and South America. In the United States, it is not approved by the US Food and Drug Administration for any medical use and it is not permitted to be sold as a dietary supplement. In the UK, piracetam is prescribed mainly for myoclonus, but is used off-label for other conditions. Evidence to support its use for many conditions is unclear.
基本信息
中文名称
乙酰胺吡咯烷酮
英文名称
2-(2-oxopyrrolidin-1-yl)acetamide
中文别名
吡拉西坦、吡乙酰胺、2-氧代-1-吡咯烷乙酰胺、2-氧代-1-吡咯烷基乙酰胺
英文别名
2-Oxo-1-pyrrolidineacetamide、Nootropil、Normabrain、Piracetam、piracetam、Nootropyl、Ciclofalina、Pyramem、Gabacet、Pyracetam、2-pyrrolidoneacetamide
CAS号
7491-74-9
分子式
C6H10N2O2
分子量
142.156
精确质量
142.074
PSA
63.4
LOGP
-0.2677
编号系统
UNII
ZH516LNZ10
物化性质
密度
1.239 g/cm3
沸点
408.3ºC at 760 mmHg
熔点
151-152ºC
闪点
200.8ºC
折射率
1.523
稳定性
Stable at normal temperatures and pressures.
储存条件
Keep tightly closed.
安全信息
RTECS号
UX9660500
安全说明
S26; S37/39
危险类别码
R36/37/38
WGK Germany
2
危险品标志
Xi
生产方法及用途
生产方法
以2-吡咯烷酮为起始原料,在甲苯中与甲醇钠成盐,与氯代乙酸乙酯缩合后再氨化制得
用途
适用于急、慢性脑血管病、脑外伤、各种中毒性脑病等多种原因所致的记忆减退及轻、中度脑功能障碍。也可用于儿童智能发育迟缓。
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