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氯噻酮

氯噻酮

CAS号:77-36-1
英文名:Chlorthalidone
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化合物简介
Chlortalidone (INN/BAN) or chlorthalidone (USAN) is a diuretic drug used to treat hypertension, originally marketed as Hygroton in the USA. It is described as a thiazide diuretic (or, rather, a thiazide-like diuretic because it acts similarly to the thiazides but does not contain the benzothiadiazine molecular structure). Compared with other medications of the thiazide class, chlortalidone has the longest duration of action but a similar diuretic effect at maximal therapeutic doses. It is often used in the management of hypertension and edema.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
由苯酐与氯苯加成、经硝化、还原得邻(3-氨基-4-氯苯甲酰)苯甲酸,然后经重氮化、置换、氯磺化,最后经环合、胺化制得。
用途
适用于心脏性、肾脏性、肝脏性及其他水肿病,与降压药合用,可增加疗效。制剂为片剂。