化合物简介
Anecortave (rINN) is a novel angiogenesis inhibitor used in the treatment of the exudative (wet) form of age-related macular degeneration. Although based on a steroid nucleus, which can be derived from cortisol, it possesses little glucocorticoid activity. It will be marketed by Alcon as anecortave acetate for depot suspension under the trade name Retaane.
基本信息
中文名称
醋酸阿奈可他
英文名称
[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
中文别名
乙酸阿奈可他
英文别名
2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate、21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion、Retaane、21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione、AL-3789、2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate、Anecortave acetate、Anecortave、Retaane suspension
CAS号
7753-60-8
分子式
C23H30O5
分子量
386.481
精确质量
386.209
PSA
80.67
LOGP
3.3017
编号系统
UNII
Y0PC411K4T
物化性质
密度
1.23g/cm3
沸点
551.8ºC at 760 mmHg
闪点
188.4ºC
折射率
1.572
生产方法及用途
用途
确炎舒松A醋酸酯、肤轻松醋酸酯、氟氢可的松醋酸酯的中间体。
上游原料
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