2'-氟-2'-脱氧尿苷

2'-氟-2'-脱氧尿苷

CAS号：784-71-4

英文名：2'-Deoxy-2'-fluorouridine

分子式

C9H11FN2O5

熔点

148 - 150 °C (乙醇)

密度

分子量

246.192

沸点

溶解度

信号词

危险品标志

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化合物简介

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

基本信息

中文名称

2'-氟-2'-脱氧尿苷

英文名称

2'-Deoxy-2'-fluorouridine

中文别名

2′-氟脱氧尿苷、2\'-脱氧-2\'-氟尿苷、DMT保护性-2‘-氟脱氧尿苷苷、2-脱氧-2-氟尿苷、2\'-氟脱氧尿苷

英文别名

2\'-Fluoro-2\'-deoxyuridine

CAS号

784-71-4

分子式

C9H11FN2O5

分子量

246.192

精确质量

246.065

PSA

104.55

LOGP

-1.8747

编号系统

UNII

Y2YC903QW8

物化性质

熔点

148 - 150 °C (乙醇)

折射率

53 ° (C=0.3, H2O)

安全信息

安全说明

S22; S36/37/39

危险类别码

R20/21/22; R40

WGK Germany

1

海关编码

29051900

危险品运输编码

UN 3181 4.1/PG 2

危险类别

4.1

包装等级

II

危险品标志

Xn

下游产品

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4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5S)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(1-hydroxyprop-2-yn-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5S)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(1-hydroxyprop-2-yn-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

4-amino-1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-fluoroethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-fluoroethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

下游产品

4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5S)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(1-hydroxyprop-2-yn-1-yl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-amino-1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-fluoroethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-amino-1-((2R,3R,4R,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-(methoxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-4-fluoro-5-[4-(3-nitro-[1,2,4]triazol-1-yl)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 1-((2R,3R,4R,5S)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-hydroxyethyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyl)pyrimidine-2,4(1H,3H)-dione 3-benzoyl-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-vinyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-3-fluoro-5-(1-fluoroethyl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one 5-{[2-(4-methoxybenzylsulfanyl)ethyl]{2-[2-(4-methoxybenzylsulfanyl)ethylamino]ethyl}amino}pent-4(E)-enyl-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(1-fluoroethyl)tetrahydrofuran-2-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one 5-(5-hydroxylpent-1(E)-enyl)-1-(3,5-diacetyl-2-fluoro-2-deoxy-1-β-D-ribofuranosyl)uracil (2R,3R,4R,5R)-2-(chloromethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((isobutyryloxy)methyl)tetrahydrofuran-3-yl isobutyrate 2-bromo-5,6-dichloro-1-(2-deoxy-3,5-di-O-acetyl-2-fluoro-β-D-ribofuranosyl)benzimidazole 1-((2R,3R,4R,5R)-5-ethyl-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethyl-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(propa-1,2-dien-1-yl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-vinyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(methoxymethyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-ethynyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxycytidine 1-((2R,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-5,5-bis(((tert-butyldimethylsilyl)oxy)methyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(2-chlorovinyl)-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(methoxymethyl)tetrahydrofuran-2-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one (((4aR,6R,7R,7aR)-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-4a-ethyl-7-fluoro-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl pivalate (2S,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-carboxylic acid (((4aR,6R,7R,7aR)-4a-ethyl-7-fluoro-6-(4-(((4-methoxyphenyl)diphenylmethyl)amino)-2-oxopyrimidin-1(2H)-yl)-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl pivalate 1-((4aR,6R,7R,7aR)-4a-ethyl-7-fluoro-2-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one ((2S,3R,4R,5R)-3-(benzyloxy)-2-((benzyloxy)methyl)-4-fluoro-5-(3-(4-methoxybenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate 1-((2R,3R,4R,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-(methoxymethyl)tetrahydrofuran-2-yl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one 4-amino-1-((2R,3R,4R,5R)-3-fluoro-5-(1-fluoroethyl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 3-(((4aR,6R,7R,7aR)-4a-ethyl-7-fluoro-6-(4-(((4-methoxyphenyl)diphenylmethyl)amino)-2-oxopyrimidin-1(2H)-yl)-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)propanenitrile 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-fluoroethyl)tetrahydrofuran-2-yl)-3-(4-methoxybenzyl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-cyclopropyl-3-fluorotetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 2,2,2-Trifluoro-N-{3-[1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-acetamide 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-5-(iodomethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one ((2R,3R,4R,5R)-5-(5-(3-aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 2,2,2-Trifluoro-N-{3-[1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-propyl}-acetamide (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-2-carbaldehyde 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(1-fluoroethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(methoxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-((R)-1-fluoroethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-5-acetyl-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluorotetrahydrofuran-2-yl)-3-(4-methoxybenzyl)pyrimidine-2,4(1H,3H)-dione