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2'-氟-2'-脱氧鸟苷

2'-氟-2'-脱氧鸟苷

CAS号：78842-13-4

英文名：2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

分子式

C10H12FN5O4

熔点

密度

分子量

285.232

沸点

溶解度

信号词

危险品标志

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化合物简介

2'-Deoxy-2'-fluoroguanosine, can be used as powerful tool for structural manipulation of G-quadruplexes. It is also a influenza viral polymerase inhibitor like Ribavirin, used as a antiviral drug against avian (H5N1) influenza virus.

基本信息

中文名称

2'-氟-2'-脱氧鸟苷

英文名称

2-amino-9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

中文别名

英文别名

2\'-fluoro guanosine、Guanosine,2\'-deoxy-2\'-fluoro、2\'-fluorodeoxyguanosine、2\'-fluorodeoxyguanisine、2\'-Dfgs、2\'-Fluoro-2\'-deoxyguanosine、2\'-Deoxy-2\'-fluoroguanosine

CAS号

78842-13-4

分子式

C10H12FN5O4

分子量

285.232

精确质量

285.087

PSA

140.27

LOGP

-1.3671

安全信息

海关编码

2934999090

合成路线

N2-异丁酰-2'-氟脱氧鸟苷

N2-异丁酰-2'-氟脱氧鸟苷

2'-氟-2'-脱氧鸟苷

2'-氟-2'-脱氧鸟苷

上游原料

共找到33个上游原料 >

2,6-dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

2,6-dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

(2R,3S,4R,5R)-2-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydrofuran-3-yl isobutyrate

(2R,3S,4R,5R)-2-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydrofuran-3-yl isobutyrate

2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine

N-(9-((2R,3S,4S,5R)-3-hydroxy-4-((tetrahydrofuran-2-yl)oxy)-5-(((tetrahydrofuran-2-yl)oxy)methyl)tetrahydrofuran-2-yl)-8-mercapto-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

N-(9-((2R,3S,4S,5R)-3-hydroxy-4-((tetrahydrofuran-2-yl)oxy)-5-(((tetrahydrofuran-2-yl)oxy)methyl)tetrahydrofuran-2-yl)-8-mercapto-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Acetic acid (2R,3S,4R,5R)-4-hydroxy-5-hydroxymethyl-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

Acetic acid (2R,3S,4R,5R)-4-hydroxy-5-hydroxymethyl-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester

N2-异丁酰-2'-氟脱氧鸟苷

N2-异丁酰-2'-氟脱氧鸟苷

上游原料

2,6-dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine (2R,3S,4R,5R)-2-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-((tetrahydro-2H-pyran-2-yl)oxy)-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydrofuran-3-yl isobutyrate 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine N-(9-((2R,3S,4S,5R)-3-hydroxy-4-((tetrahydrofuran-2-yl)oxy)-5-(((tetrahydrofuran-2-yl)oxy)methyl)tetrahydrofuran-2-yl)-8-mercapto-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide Acetic acid (2R,3S,4R,5R)-4-hydroxy-5-hydroxymethyl-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester N2-异丁酰-2'-氟脱氧鸟苷 1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranoside N2-isobutyryl-9-(2-O-isobutyryl-3,5-O-(tetraisopropyldisiloxanylene)-β-D-arabinofuranosyl)guanine (6aR,8R,9S,9aR)-8-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl acetate N2-isobutyryl-9-(2-O-isobutyryl-β-D-arabinofuranosyl)guanine 3’,5’-O-(1,1,3,3-四异丙基-1,3-二硅氧烷)鸟苷 N2-isobutyryl-9-(2-fluoro-3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine Trifluoro-methanesulfonic acid (2R,3S,4R,5R)-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl ester 2,6-diazido-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine N2-isobutyryl-9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]guanine 2,6-diamino-9-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)purine N2-isobutyryl-3'-O,5'-O-(tetrahydrofuranyl)-8,2'-anhydro-8-oxy-9-β-D-arabinofuranosylguanine (6aS)-2-amino-7c-hydroxy-8t-hydroxymethyl-(6ar,9ac)-6a,7,8,9a-tetrahydro-3H-furo[2',3':4,5]oxazolo[3,2-e]purin-4-one 2'-脱氧-2-氟胞苷 2-氨基-2'-氟-2'-脱氧腺苷 9-(3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl)guanine 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-ketoguanosine 1-(2-deoxy-2-fluoro-β-D-xylofuranosyl)uracil 9-beta-D-呋喃阿拉伯糖基-2,6-二氨基嘌呤 2,6-二氯嘌呤 N2-isobutyryl-8,2'-anhydro-8-oxy-9β-D-arabinofuranosylguanine 9-β-D-糖呋喃鸟嘌呤 2,6-二氨基嘌呤 N2-isobutyryl-3'-O,5'-O-bis(tetrahydrofuranyl)-9β-D-arabinofuranosylguanine N2-isobutyryl-3'-O,5'-O-bis(tetrahydrofuranyl)-2'-deoxy-2'-fluoroguanosine tetraisopropyldisiloxanyl (TPDS) protected 9-beta-D-arabinofuranosylguanine