化合物简介
Iloprost is a drug used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and other diseases in which the blood vessels are constricted and blood can't flow to the tissues. This damages the tissues and causes high blood pressure. Iloprost works by opening (dilating) the blood vessels to allow the blood to flow through again. It was developed by the pharmaceutical company Schering AG and is marketed by Bayer Schering Pharma AG in Europe and Actelion Pharmaceuticals in the USA.
基本信息
中文名称
伊洛前列素
英文名称
iloprost
中文别名
英文别名
Ataprost [INN]、Ataprostum、Iloprost、5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-bicyclo[3.3.0]octa-3-ylidene)-pentanoic acid、5-{(E)-(1S,5S,6R,7R)-7-hydroxy-6-[(E)-(3S,4RS)-3-hydroxy-4-methyl-5-octen-6-inyl]-bicyclo[3.3.0]-octan-3-ylidene}pentenoic acid、Pentanoic acid,5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-,(3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha))、Ataprost、Ataprostum [INN-Latin]
CAS号
78919-13-8
分子式
C22H32O4
分子量
360.487
精确质量
360.23
PSA
77.76
LOGP
3.5413
编号系统
UNII
JED5K35YGL
物化性质
外观与性状
无色油状
密度
1.21g/cm3
沸点
539.2ºC at 760 mmHg
熔点
115.7ºC
闪点
294ºC
折射率
1.629
储存条件
Desiccate at -20ºC
安全信息
海关编码
2918199090
合成路线
上游原料
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