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5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

CAS号：804551-97-1

英文名：5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

分子式：C39H35ClN4O3S

分子量：675.238

合成路线

(E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-yn-1-ol

(E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-yn-1-ol

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

(1R,2S)-1-chloro-2-(2,2-dibromo-vinyl)-cyclopropane

(1R,2S)-1-chloro-2-(2,2-dibromo-vinyl)-cyclopropane

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

(1S,2R)-1-((E)-5-bromo-pent-3-en-1-ynyl)-2-chloro-cyclopropane

(1S,2R)-1-((E)-5-bromo-pent-3-en-1-ynyl)-2-chloro-cyclopropane

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

[(E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-ynyl]-phosphonic acid diethyl ester

[(E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-ynyl]-phosphonic acid diethyl ester

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

5-[(5E,7E)-(2S,4R)-10-((1S,2R)-2-chloro-cyclopropyl)-4-trityloxy-deca-5,7-dien-9-yne-2-sulfonyl]-1-phenyl-1H-tetrazole

上游原料

(1S,2R)-1-((E)-5-bromo-pent-3-en-1-ynyl)-2-chloro-cyclopropane (E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-yn-1-ol [(E)-5-((1S,2R)-2-chloro-cyclopropyl)-pent-2-en-4-ynyl]-phosphonic acid diethyl ester (1R,2S)-1-chloro-2-(2,2-dibromo-vinyl)-cyclopropane

下游产品

(E)-(5R,9R,10R,11S,12S,13R)-13-(tert-Butyl-dimethyl-silanyloxy)-5-[(1E,3E)-6-((1S,2R)-2-chloro-cyclopropyl)-hexa-1,3-dien-5-ynyl]-9-methoxy-7,10,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadeca-1(14),7-dien-3-one