化合物简介
(R)-(+)-Thiolactomycin is a natural product inhibitor of β-Ketoacyl-AcpM Synthase A (KasA). It inhibits the synthesis of mycolic acid which is a major cell wall component of Mycobacterium tuberculosis. Also an inhibitor of D-Aspartate oxidase (DDO).
基本信息
中文名称
乳霉素
英文名称
(2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one
中文别名
英文别名
(+)-Thiolactomycin、(R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one、TLM、[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone、(5R)-4-hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5-H-thiophen-2-one、2(5H)-Thiophenone,3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-,(R-(E))、(R)-(+)-Thiolactomycin、5R-Thiolactomycin、(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone、Antibiotic 2-200
CAS号
82079-32-1
分子式
C11H14O2S
分子量
210.293
精确质量
210.071
PSA
62.6
LOGP
2.9828
编号系统
RTECS号
XN1928870
MDL号
MFCD01940028
PubChem号
24278631
物化性质
密度
1.214g/cm3
沸点
319.2ºC at 760 mmHg
闪点
146.8ºC
折射率
1.632
上游原料
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