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非索芬那定

非索芬那定

CAS号:83799-24-0
英文名:fexofenadine
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化合物简介
非索非那定(Fexofenadine),贩卖药名为艾来锭(Allegra),剂型为60mg或180mg锭剂。是特芬那定(Terfenadine)衍生而来的活性代谢物,它是一种具有选择性末稍H1接受体拮抗活性的抗组织胺药。非索非那定的两种镜像异构物均可显现效力相当的抗组织胺作用,被称为第二代抗组织胺的它不会通过大脑血管障壁(blood brain barrier,BBB),不会有前代制品例如嗜睡等等的副作用。
基本信息
编号系统
物化性质
安全信息
生产方法及用途
用途
呼吸系统及抗过敏用药,用于治疗季节性过敏性鼻炎、慢性突发性风疹等
上游原料
2-[4-(4-Chlorobutanoyl)phenyl]-2-methylpropyl acetate methyl 2-(4-(4-bromo-1,1-dimethoxybutyl)phenyl)-2-methyl-propanoate 4-((4-(4-羟基二苯甲基)-1-哌啶基)-1-氧代丁基)-a,a-二甲基苯乙酸 4-[4-(甲烷磺酰基氧基)-1-丁炔基]-alpha,alpha-二(甲基)苯乙酸,甲酯 Methyl 2-[4-(1-hydroxy-4-chlorobutyl)phenyl]isobutyrate 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)-1,1-dimethoxybutyl)phenyl)-2-methyl-propanoic acid 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutanol 非索非那定甲酯 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile alpha,alpha-二甲基苯乙酸 2-[4-(3-[1,3]Dioxolan-2-yl-1-hydroxy-propyl)-phenyl]-2-methyl-propionic acid ethyl ester 2-(4-溴苯基)-2-甲基丙酸 4-(4-(2-cyanopropan-2-yl)phenyl)-4-oxobutyl 4-methylbenzenesulfonate 4-(1-ethoxy-2-methyl-1-oxopropan-2-yl)benzoic acid ethyl 2-(4-formylphenyl)-2-methylpropanoate 4-[4-氯-1-丁酰基]-A,A-二甲基苯乙酸甲酯 methyl 4-(4-bromo-1-oxobutyl)-α,α-dimethylphenylacetate (2-甲基-2-苯基-丙基)乙酸酯 sodium (4-(2-cyanopropan-2-yl)phenyl)(2-oxodihydrofuran-3(2H)-ylidene)methanolate 2-methyl-2-p-tolyl-propionic acid ethyl ester 特非那定 {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol 4-羟基二苯基甲基哌啶-1-羧酸苄酯 2-(4-溴苯基)-2-甲基丙腈 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyric acid 2-(4-(4-hydroxybutanoyl)phenyl)-2-methylpropanenitrile 4-(4-羟基-1-丁炔l)-|á,|á-二甲基苯乙酸甲酯 Methyl 2-[4-(1-ethylendioxo-4-chlorobutyl)phenyl]isobutyrate methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)-1,1-dimethoxybutyl)phenyl)-2-methyl-propanoate 1-脱羟基-1-去氢-非索非那定-d6甲酯 对氰基甲基苯甲酸甲酯 methyl 2-(4-(4-chloro-1,1-dimethoxybutyl)phenyl)-2-methyl-propanoate 2-(4-溴苯基)-2,2-二甲基乙酸甲酯 α,α-二苯基-4-哌啶甲醇 methyl 2-(4-(2-methoxytetrahydrofuran-2-yl)phenyl)-2-methyl-propanoate ethyl 2-(4-(3-(1,3-dioxolan-2-yl)propanoyl)phenyl)-2-methylpropanoate 2-甲基-2-苯基丙烷-1-醇 盐酸非索非那定 4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butanal 2,2-二甲基苯乙酸甲酯 sodium 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoate 4-哌啶甲酸乙酯 1-Cbz-哌啶-4-甲酸乙酯 ethyl 2-(4-(chlorocarbonyl)phenyl)-2-methylpropanoate N-methoxy-N-methyl-2-(4-{1-hydroxy-4-[4-(hydroxy-diphenylmethyl)-piperidine-1-yl]-butyryl}-phenyl)-isobutyramide 2-(4-Bromomethyl-phenyl)-2-methyl-propionic acid ethyl ester 4-(4-羟基联苯甲基)哌啶-1-氧代丁基-2,2-二甲基苯乙酸甲酯 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile