化合物简介
Lupitidine (INN) (code name SKF-93479), or lupitidine hydrochloride (USAN), is a long-acting H2 receptor antagonist developed by Smith, Kline & French and described as an antiulcerogenic that was never marketed. It was shown to inhibit nocturnal gastric acid secretion and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.
基本信息
中文名称
鲁匹替丁
英文名称
2-[2-[[5-(2-aminopropan-2-yl)furan-2-yl]methylsulfanyl]ethylamino]-5-[(6-methylpyridin-3-yl)methyl]-1H-pyrimidin-6-one
中文别名
英文别名
2-[2-(5-dimethylaminomethyl-2-furylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone、LUPITIDINE、Lupitidine [INN]、Lupitidinum、2-[2-(5-dimethylaminomethyl-furan-2-ylmethylthio)ethylamino]-5-(6-methyl-pyridin-3-ylmethyl)-4-pyrimidone、2-[[2-[[[5-[(dimethylamino)methyl]-furan-2-yl]methyl]thio]ethyl]amino]-5-(6-methyl-3-pyridinyl)methyl-4(1H)-pyrimidinone、UNII-WF028DWK9N、Lupitidinum [Latin]、2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidinone、2-[2-(5-dimethylaminomethyl-2-furanylmethylthio)ethylamino]-5-(6-methyl-pyridin-3-ylmethyl)-4-pyrimidone
CAS号
83903-06-4
分子式
C21H27N5O2S
分子量
413.536
精确质量
413.189
PSA
112.35
LOGP
3.137
编号系统
UNII
WF028DWK9N
物化性质
密度
1.25g/cm3
沸点
559.4ºC at 760 mmHg
闪点
292.1ºC
折射率
1.629
